| Evaluation of ethylcellulose as matrices for controlled release drug delivery. | |
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MedLine Citation:
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PMID: 16431395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the efficiency of a matrix forming polymer in sustaining drug release is a multiple function of physico-chemical nature of the active ingredient and pH of the surrounding environment, the study was undertaken to evaluate the effect of pH of dissolution media on the release profile of three drug molecules with diversified physico-chemical properties. Matrix tablets of diclofenac sodium, theophylline and diltiazem HCl were prepared using ethylcellulose as the matrix forming agent. The drug dissolution behavior of the matrix tablets were studied over 10 hours in buffer media of pH 1.2, 4.5 and 6.8. Elevation of pH of the dissolution medium increased the rate and extent of diclofenac release. However, for diltiazem HCl, increasing the pH showed the reverse pattern. Theophylline release, on the other hand, seemed to be unaffected by the pH of the dissolution media. This can be correlated with the physico-chemical characteristics of the drugs. Effect of compression force on drug release and tablet hardness was also studied. Increasing the compression force reduced drug release irrespective of the chemical nature of the drug molecule which can be attributed to the reduction of porosity and formation of continuous polymeric network within the matrix. Again, no significant change in tablet hardness was found with the increment of compression force. A near zero-order release kinetics were observed in all formulations investigated. |
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Authors:
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Mohiuddin Abdul Quadir; Eva Chanda; Syed Shabbir Haider; M D Selim Reza; Biddyut Kanti Datta |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 18 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Faculty of Pharmacy University of Dhaka, Dhaka 1000, Bangladesh. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cellulose
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analogs & derivatives*,
chemistry Compressive Strength Delayed-Action Preparations / chemistry*, pharmacokinetics Diclofenac / chemistry, pharmacokinetics Diltiazem / chemistry, pharmacokinetics Drug Carriers / chemistry* Hydrogen-Ion Concentration Kinetics Solubility Tablets Technology, Pharmaceutical / methods Theophylline / chemistry, pharmacokinetics Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Drug Carriers; 0/Tablets; 15307-86-5/Diclofenac; 42399-41-7/Diltiazem; 58-55-9/Theophylline; 9004-34-6/Cellulose; 9004-57-3/ethyl cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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