| Evaluation of esterified hyaluronic acid as middle ear-packing material. | |
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MedLine Citation:
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PMID: 11346429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy of esterified hyaluronic acid (MeroGel) as a middle ear (ME)-packing material. DESIGN: Randomized controlled trial. MATERIAL: Twenty-four guinea pigs. INTERVENTION: Group 1, MeroGel-treated animals (n = 10), bilateral wounding of ME mucosa with 5 of the animals receiving the MeroGel packing in the left ME and 5 of the animals receiving MeroGel in the right ME; group 2, absorbable gelatin sponge-treated animals (n = 10), with the same experimental protocol as in group 1 except that the absorbable gelatin sponge was the packing material; group 3, untreated animals (n = 4), unilateral wounding of the left ME mucosa in 2 animals and in 2 animals in the right ME, with no packing material. Auditory brainstem recordings were performed for all groups before the ME operation and 5 days and 6 weeks after the operation. RESULTS: Auditory brainstem response recordings at postoperative day 5 showed that all ears with ME packing had hearing losses in the frequency range of 500 to 4000 Hz. The recovery of hearing acuity at postoperative week 6 was significantly better in group 1 (MeroGel-treated) guinea pigs compared with group 2 (the absorbable gelatin sponge-treated) animals. In group 2 animals, 20% of the packing material remained in the ME cavities and new bone formation was observed, while in group 1 animals, there was less packing material in the ME and no formation of new bone. CONCLUSIONS: MeroGel is a nonototoxic packing material with a high level of biocompatibility for ME mucosa; it is an effective supportive material following ME surgery and is easily expelled from the ME cavity. |
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Authors:
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G Li; J G Feghali; E Dinces; J McElveen; T R van de Water |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of otolaryngology--head & neck surgery Volume: 127 ISSN: 0886-4470 ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-10 Completed Date: 2001-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 534-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / pharmacokinetics*, toxicity Ear, Middle / drug effects*, injuries, surgery Esterification Gelatin Sponge, Absorbable Guinea Pigs Hearing / drug effects Hyaluronic Acid / pharmacology*, toxicity Mucous Membrane / drug effects Random Allocation Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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