Document Detail


Evaluation of esophageal transit of tablets and capsules in 30 cats.
MedLine Citation:
PMID:  11596734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have reported tablet-induced focal esophagitis and esophageal stricture formation in cats. The proposed mechanism is thought to be abnormal esophageal tablet retention resulting in focal esophagitis with subsequent stricture formation. The objective of this study was to evaluate the passage of tablets and capsules when given alone (dry swallow) and when followed by a water bolus (wet swallow) to determine if this could, in part, explain the esophageal stricture formation we have observed in cats. Fluoroscopy was used to evaluate tablet or capsule passage after administration. The percentage of dry tablet swallows that successfully passed into the stomach was 0.0% at 30 and 60 seconds, 6.7% at 90 seconds, 13.3% at 120 seconds, 26.7% at 180 and 240 seconds, and 36.7% at 300 seconds. Wet tablet swallows successfully passed 90.0% of the time at 30 seconds, 93.3% of the time at 60 seconds, and 100.0% of the time thereafter. The percentage of dry capsule swallows that successfully passed was 16.7% at each time interval. Wet capsule swallows successfully passed 96.7% of the time at 30 seconds and 100% of the time thereafter. For each time interval, wet swallows achieved significantly greater percentage passage into the stomach when compared to dry swallows (P < .05). This study shows that tablets or capsules given by dry swallow have prolonged retention in the esophagus compared to those given by wet swallow. On the basis of this study, we recommend the routine administration of a water bolus to cats receiving tablets or capsules PO to facilitate esophageal clearance. This practice may help prevent medication-associated esophagitis or stricture formation.
Authors:
D S Westfall; D C Twedt; P F Steyn; E B Oberhauser; J W VanCleave
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  15     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-10-12     Completed Date:  2002-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Capsules / administration & dosage
Cat Diseases / prevention & control
Cats / physiology*
Esophageal Stenosis / prevention & control,  veterinary
Esophagus / physiology*,  radiography
Female
Gastrointestinal Transit / physiology*
Male
Reference Values
Tablets / administration & dosage
Time Factors
Veterinary Drugs / administration & dosage*
Chemical
Reg. No./Substance:
0/Capsules; 0/Tablets; 0/Veterinary Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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