| Evaluation of esophageal function in patients with gastroesophageal reflux disease using transnasal endoscopy. | |
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MedLine Citation:
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PMID: 19788608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: To investigate the utility of a new method of carrying out esophageal manometry using a narrow gauge manometry catheter via a transnasal endoscope. METHODS: The Frequency Scale for the Symptoms of gastroesophageal reflux disease (GERD) (FSSG), a GERD-specific questionnaire, was given to 45 subjects. Subjects underwent transnasal endoscopy with three dry and three wet (3 mL water) swallows. Direct observations of the primary peristaltic wave and peristaltic pressure measurement were conducted simultaneously. RESULTS: Endoscopic observation of lower esophageal motility associated with swallowing revealed dilatation of the esophageal lumen after swallowing, followed by contraction in association with the primary peristaltic wave. The peristaltic pressure was significantly lower with increased FSSG scores for dry swallows (r = -0.347, P = 0.0212), but no significant correlation was seen for wet swallows. CONCLUSIONS: The significant negative correlation between reflux symptoms and peristaltic pressure in dry swallows was thought to be that reduced pressure immediately rostral to the lower esophageal sphincter leads to decreased clearance following gastric acid reflux, playing a large part in the onset of symptoms. |
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Authors:
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Shigeaki Yasaka; Kazunari Murakami; Takashi Abe; Juro Anan; Kazuhiro Mizukami; Jin Tanahashi; Tadayoshi Okimoto; Masaaki Kodama; Yoshikuni Kudo; Hisanori Kawasaki; Toshio Fujioka |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 24 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-30 Completed Date: 2009-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 1677-82 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan. s.yasaka@med.oita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antibodies, Bacterial / blood Deglutition* Endoscopes, Gastrointestinal Endoscopy, Digestive System / methods* Equipment Design Esophagus / microbiology, physiopathology* Female Gastroesophageal Reflux / complications, diagnosis*, microbiology, physiopathology Helicobacter pylori / immunology Humans Male Manometry / instrumentation, methods* Middle Aged Nasal Cavity* Peristalsis* Predictive Value of Tests Pressure Questionnaires Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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