| Evaluation of esophageal cancer by positron emission tomography. | |
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MedLine Citation:
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PMID: 12417599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A retrospective study was performed to determine the indications for positron emission tomography (PET) using [(18)F]fluorodeoxyglucose (FDG) in patients with esophageal cancer, including those with early cancer, and to investigate whether the tumor-to-normal ratio (T/N ratio) could be used as a substitute for the standardized uptake value (SUV). METHODS: Thirty-six patients were included in the study. Thirty-one patients who had 36 biopsy-proven lesions (35 squamous cell carcinomas and one small cell carcinoma) underwent PET study prior to treatment. PET images were evaluated visually and the relationship between the depth of invasion and the PET findings were examined in 22 lesions of 19 patients from whom specimens were obtained from the primary tumor by surgery or endoscopic mucosal resection. PET results were also compared with computed tomography (CT) and endoscopic ultrasonography (EUS) for detection of regional lymph node metastases in 18 patients who underwent extended lymph node dissection. Five patients underwent PET studies for the detection of recurrence and the PET findings were compared with their CT findings. The T/N ratio and the SUV were calculated for 20 primary tumors. RESULTS: Among the 15 tumors that were pT1b or greater, all 15 were positive on PET and all seven of the lesions confined to the mucosa (Tis or T1a) were negative. The sensitivity, specificity and accuracy of detecting nodal involvement were, respectively, 37.5, 96.1 and 88.3% by CT, 30.8, 88.5 and 81.0% by EUS and 41.7, 100 and 92.2% by PET. More sites of recurrence were detected by PET than by CT. There was no statistically significant correlation between the SUV and the T/N ratio. CONCLUSIONS: PET imaging can detect primary esophageal cancer with a depth of invasion of T1b or greater, but Tis and T1a tumors are undetectable. PET seems to be more accurate than CT or EUS for diagnosing lymph node metastasis. The T/N ratio cannot be used as a substitute for the SUV. |
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Authors:
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Shinji Himeno; Seiei Yasuda; Hideo Shimada; Tomoo Tajima; Hiroyasu Makuuchi |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Japanese journal of clinical oncology Volume: 32 ISSN: 0368-2811 ISO Abbreviation: Jpn. J. Clin. Oncol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2002-11-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0313225 Medline TA: Jpn J Clin Oncol Country: Japan |
Other Details:
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Languages: eng Pagination: 340-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan. shinhi-h@de4.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Squamous Cell / radiography, radionuclide imaging*, secondary Esophageal Neoplasms / pathology, radiography, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use Humans Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Radiopharmaceuticals / diagnostic use Retrospective Studies Tomography, Emission-Computed* / standards Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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