Document Detail


Evaluation of an enzyme immunoassay for clinical diagnosis of neurocysticercosis in symptomatic patients.
MedLine Citation:
PMID:  21181016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Neurocysticercosis is an infection of the human central nervous system caused by the metacestode larvae of Taenia solium. Neurocysticercosis is the most common parasitic disease in developing countries. Epilepsy is the most common clinical manifestation. Difficulties in confirming the diagnosis motivated the evaluation of the enzyme-linked immunosorbent assay on cerebral spinal fluid (CSF).
METHODS: Twenty-two patients with NCC and 44 control patients were studied. CSF was analyzed using a commercial ELISA kit developed for NCC. Sensitivity and specificity were measured and a multivariate logistic regression was performed.
RESULTS: Sensitivity and specificity of ELISA were 31.8% and 100%, respectively, with accuracy of 77.3%. Only the size of the lesions proved to be important for performance of the test.
CONCLUSIONS: The results showed that ELISA contributes to the diagnosis of neurocysticercosis if the result is negative or if the patient has a lesion of 2 cm or more.
Authors:
Reynaldo Mendes de Carvalho Junior; Dorcas Lamounier Costa; Savyo Carvalho Soares; Carlos Henrique Nery Costa
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista da Sociedade Brasileira de Medicina Tropical     Volume:  43     ISSN:  1678-9849     ISO Abbreviation:  Rev. Soc. Bras. Med. Trop.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-09-29     Revised Date:  2011-10-04    
Medline Journal Info:
Nlm Unique ID:  7507456     Medline TA:  Rev Soc Bras Med Trop     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  647-50     Citation Subset:  IM    
Affiliation:
Department of Specializing Medicine, Federal University of Piaui, Teresina, PI, Brazil. reynaldomendes@globo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Antibodies, Helminth / cerebrospinal fluid*
Case-Control Studies
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Meningitis, Viral / cerebrospinal fluid,  diagnosis*
Middle Aged
Neurocysticercosis / cerebrospinal fluid,  diagnosis*
Sensitivity and Specificity
Taenia solium / immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Antibodies, Helminth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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