| Evaluation of endovascular techniques for creating a porcine femoral artery occlusion model. | |
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MedLine Citation:
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PMID: 11552732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the optimal endovascular approach to achieve long-term occlusion of large arteries, while preserving the integrity of periarterial tissue, in an animal model of ischemia. METHODS: Femoral artery occlusions were created in 16 pigs using detachable balloons, coils, or blinded stent-grafts. Feasibility, safety, primary and long-term success, and the degree of neovascularization were determined over a 6-month period by serial angiography and histological analyses. Four animals served as untreated controls. RESULTS: Overall primary success for all occlusion devices was 100%. The 6-month occlusion rate using detachable balloons or coils was 33% and 0%, respectively; however, all arteries occluded with blinded stent-grafts remained obstructed to the end of the study. There was no significant difference in capillary densities and collateralization of periarterial areas when occluded arteries were compared with nonoccluded controls in the same animal. No increase in collateralization was observed following endovascular arterial occlusion. CONCLUSIONS: Percutaneous insertion of blinded stent-grafts easily, safely, and reliably creates long-term arterial occlusion in pigs, which may make this a more appropriate model for studying the effects of angiogenic factors in vivo. |
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Authors:
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S Nikol; S Armeanu; M G Engelmann; J Pelisek; A Fuchs; C Zähringer; J M Bartoli; T Mesana; P H Rolland |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 8 ISSN: 1526-6028 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-12 Completed Date: 2002-01-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 401-7 Citation Subset: IM |
Affiliation:
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Medical Department I, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany. s-nikol@gmx.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anatomy, Cross-Sectional Animals Arterial Occlusive Diseases / surgery* Catheterization Disease Models, Animal Extremities / blood supply Femoral Artery / anatomy & histology, radiography, surgery* Follow-Up Studies Stents Swine Time Time Factors Vascular Surgical Procedures* / instrumentation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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