Document Detail

Evaluation and endoscopic palliation of cholangiocarcinoma. Management of cholangiocarcinoma.
MedLine Citation:
PMID:  10754358     Owner:  NLM     Status:  MEDLINE    
Patients with a cholangiocarcinoma usually develop symptoms of biliary obstruction which dominate the course of their illness. At presentation, the diagnosis may be difficult to establish due to the desmoplastic nature of this tumor. Location and extent of the tumor, however, are more effectively evaluated by current radiologic techniques. Following these staging procedures, most patients are found to be unsuitable for curative resection. Therefore, establishing effective biliary drainage to relieve symptoms of obstruction becomes the most critical therapeutic goal in these patients. In the past, surgical biliary bypass procedures were advocated, but were associated with high perioperative morbidity and mortality rates. Endoscopic biliary stenting produces quick and effective relief of symptoms from biliary obstruction due to cholangiocarcinoma. Initially, successful biliary drainage is possible in most patients. However, subsequent stent occlusion or spread of tumor into nonstentable intrahepatic ducts leads to recurrent jaundice. Local therapies including (192)Ir brachytherapy and photodynamic therapy may prevent or postpone these problems.
A Rumalla; T H Baron
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  17     ISSN:  0257-2753     ISO Abbreviation:  Dig Dis     Publication Date:  1999  
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  194-200     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minn., USA.
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MeSH Terms
Bile Duct Neoplasms / diagnosis,  therapy*
Bile Ducts, Intrahepatic*
Cholangiocarcinoma / diagnosis,  therapy*
Cholangiopancreatography, Endoscopic Retrograde*
Clinical Trials as Topic
Palliative Care / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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