| Evaluation of endoscopic hemostasis with metallic hemoclips for bleeding gastric ulcer: comparison with endoscopic injection of absolute ethanol in a prospective, randomized study. | |
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MedLine Citation:
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PMID: 14572568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although metallic hemoclips have been used for hemostasis of bleeding ulcer, there have been few prospective trials to evaluate their efficacy. In this study, a prospective, randomized trial was performed to evaluate endoscopic hemoclipping for bleeding gastric ulcer in comparison with endoscopic injection of absolute ethanol. METHODS: During the period 1995-1998, 126 gastric ulcer patients with bleeding or nonbleeding visible vessel were considered for entry. They were randomly assigned to one of three groups: endoscopic hemostasis performed with injection of absolute ethanol (group I, n = 42), hemoclipping (group II, n = 42), and a combination of the two methods (group III, n = 42). RESULTS: The permanent hemostatic rate was 85.7% in group I, 90.5% in group II, and 92.9% in group III. The mean volume of blood transfusion was 313 +/- 77 ml in group I, 274 +/- 54 ml in group II, and 163 +/- 42 ml in group III, which was significantly less than in groups I or II (p < 0.05). No patients required emergency surgery. Five patients died within a month after initial hemostasis as a result of unrelated conditions. CONCLUSIONS: Endoscopic hemostasis with hemoclips for bleeding gastric ulcer was as effective and safe as that with injection of absolute ethanol, and a combination of ethanol injection and hemoclips did not result in a great advantage over the two individual procedures. |
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Authors:
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Ryo Shimoda; Ryuichi Iwakiri; Hiroyuki Sakata; Shinichi Ogata; Atsushi Kikkawa; Hibiki Ootani; Kayoko Oda; Akifumi Ootani; Seiji Tsunada; Kazuma Fujimoto |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Evaluation Studies; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 98 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-23 Completed Date: 2003-11-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 2198-202 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Saga Medical School, Nabeshima, Saga, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Equipment Design Ethanol / administration & dosage* Female Follow-Up Studies Hemostasis, Endoscopic / instrumentation*, methods Humans Injections, Intralesional Male Metals Middle Aged Peptic Ulcer Hemorrhage / diagnosis, therapy* Prospective Studies Reference Values Sclerosing Solutions / therapeutic use Sensitivity and Specificity Severity of Illness Index Stomach Ulcer / diagnosis, therapy* Surgical Instruments Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Sclerosing Solutions; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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