Document Detail

Evaluation of electrophysiological and clinical tests in an exploratory trial of Org 2766 in motor neuron disease.
MedLine Citation:
PMID:  8268729     Owner:  NLM     Status:  MEDLINE    
Twenty four patients with motor neuron disease (MND) participated in a double-blind, placebo-controlled trial with the ACTH 4-9 analog, Org 2766. Patients were examined three times during an 8 week treatment period, using a summated score for several manually and functionally tested muscles (sum score), myometry, jitter, fibre density (FD), macro motor unit potential (MUP), and supramaximal evoked muscle action potentials. No differences were found between Org 2766 and placebo treated patients. In an open 1 yr follow-up study, 5 out of 13 patients treated with Org 2766 died; the others showed continued progression of weakness. The methods used for assessment of muscle function were compared. The highest interest reliability was obtained in the sum score and myometry. Mean differences that might be detectable were relatively small for the sum score and myometry, and large for FD and MUP. We concluded that clinical function testing and myometry are superior to electromyographic measurements for assessment of changes in MND patients.
L F Hesselmans; G H Wieneke; P L Oey; D M Groenhout; Y van der Graaf; W H Gispen; F G Jennekens
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  3     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1994-02-01     Completed Date:  1994-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-25     Citation Subset:  IM    
Division of Neuromuscular Diseases, Rudolf Magnus Institute, Utrecht, The Netherlands.
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MeSH Terms
Action Potentials
Adrenocorticotropic Hormone / analogs & derivatives*,  therapeutic use
Analysis of Variance
Anticonvulsants / therapeutic use
Double-Blind Method
Electrophysiology / methods
Evoked Potentials
Follow-Up Studies
Isometric Contraction / drug effects
Middle Aged
Motor Neuron Disease / drug therapy*,  physiopathology*
Multivariate Analysis
Muscles / physiopathology*
Peptide Fragments / therapeutic use*
Time Factors
Reg. No./Substance:
0/Anticonvulsants; 0/Peptide Fragments; 0/Placebos; 50913-82-1/Org 2766; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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