Document Detail

Evaluation of the electrochemical behavior and analytical potentialities of a carbon paste electrode modified with a ruthenium (III) piperidinedithiocarbamate complex.
MedLine Citation:
PMID:  15752473     Owner:  NLM     Status:  MEDLINE    
The preparation and electrochemical characterization of a carbon paste electrode modified with bis(N,N-piperidinedithiocarbamate)-mu-tris(N,N-piperidinedithiocarbamate)diruthenium(III) complex, alpha-[Ru2(Pip)5]Cl are described. The best voltammetric response was obtained for a 10% (m/m) alpha-[Ru2(Pip)5]Cl content in the paste, potassium acid phthalate solution pH 4.0 as supporting electrolyte and scan rate of 100 mV s-1. The analytical potentialities of the electrode have been evaluated using L-ascorbic acid (vitamin C) as a probe. A sensitive linear voltammetric response for L-ascorbic acid was obtained in the concentration range 4.50-113x10(-5) mol l-1 (7.92-200 mg l-1) with a slope of 1.12x10(4) microA mol-1, and a detection limit (3sigma/slope) of 7.00x10(-6) mol l-1 using cyclic voltammetry. The concentrations of L-ascorbic acid in pharmaceutical formulations (tablets and liquid) were determined using the modified electrode and compared with an iodimetric procedure with good agreement at the 95% confidence and relative error lower than 1%.
Luiz Antônio Ramos; Eder Tadeu Gomes Cavalheiro; Gilberto Orivaldo Chierice
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  60     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Departamento de Química e Física Molecular, Instituto de Química de São Carlos, USP Caixa Postal 780, CEP 13560-970, São Carlos, SP, Brazil.
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MeSH Terms
Ascorbic Acid / pharmacology
Carbon / chemistry*
Hydrogen-Ion Concentration
Pharmaceutical Preparations / chemistry
Piperidines / chemistry*
Reproducibility of Results
Ruthenium / chemistry*
Sensitivity and Specificity
Thiocarbamates / chemistry*
Reg. No./Substance:
0/Pharmaceutical Preparations; 0/Piperidines; 0/Thiocarbamates; 50-81-7/Ascorbic Acid; 7440-18-8/Ruthenium; 7440-44-0/Carbon

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