Document Detail


Evaluation of the efficacy and tolerability of nitrendipine in reducing both pressure and left ventricular mass in hypertensive type 2 diabetic patients.
MedLine Citation:
PMID:  9250456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy and tolerability of nitrendipine in comparison with captopril in hypertensive diabetic patients with left ventricular hypertrophy (LVH). RESEARCH DESIGN AND METHODS: A total of 75 patients enrolled in this study presented stable type 2 diabetes (not treated with insulin) and mild-to-moderate hypertension with a left ventricular mass > or = 75 g/m2 by two-dimensional echocardiography. After a 4-week washout period, 38 patients were assigned to treatment with captopril, and 37 patients to nitrendipine (random allocation). The duration of follow-up was 36 weeks. RESULTS: Patients of both groups were similar with regard to the duration of diabetes and hypertension, systolic and diastolic blood pressure at rest, degree of LVH, metabolic control, and albumin excretion rate (AER). Both drugs were equally effective in reducing systolic and diastolic blood pressure (captopril: from 165 +/- 13/100 +/- 4 to 147 +/- 11/87 +/- 4 mmHg; nitrendipine: from 167 +/- 17/100 +/- 5 to 143 +/- 9/86 +/- 4 mmHg; P < 0.05) and in reversing LVH (nitrendipine: from 87 +/- 2 to 81 +/- 1 g/m2; captopril: from 89 +/- 2 to 85 +/- 2 g/m2; P = 0.0001). Neither the left ventricular end-diastolic volume index nor the left ventricular ejection fraction changed significantly during the treatment period. CONCLUSION: Nitrendipine is as effective as captopril in reducing both systolic and diastolic blood pressure and in reversing LVH. Neither drug showed any negative side effects on fasting plasma glucose and glycated hemoglobin (HbA1c) levels, and both maintain constant AERs.
Authors:
R Scognamiglio; R Nosadini; M Marin; S Nisti; G Fasoli; M Palisi; F Frigato; F Virgili; A Carraro; G Crepaldi
Related Documents :
7525196 - Trandolapril. a review of its pharmacodynamic and pharmacokinetic properties, and thera...
8723396 - Improvement of vagal tone by ace inhibition: a mechanism of cardioprotection in patient...
10986156 - Rationale for angiotensin ii receptor blockers in patients with low-renin hypertension.
20448636 - Antihypertensive effects of ocimum basilicum l. (obl) on blood pressure in renovascular...
9160766 - Does orthostatic testing have any role in the evaluation of the young subject with mild...
14533526 - Inverse relationship between blood volume and blood pressure.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Diabetes care     Volume:  20     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-15     Completed Date:  1997-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1290-2     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Padua University Medical School, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  therapeutic use
Blood Glucose / metabolism
Blood Pressure / drug effects*
Calcium Channel Blockers / adverse effects,  therapeutic use*
Captopril / adverse effects,  therapeutic use
Diabetes Mellitus, Type 2 / blood,  complications*,  physiopathology
Double-Blind Method
Drug Evaluation
Drug Tolerance
Echocardiography
Female
Follow-Up Studies
Humans
Hypertension / complications,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / complications,  drug therapy*,  ultrasonography
Male
Middle Aged
Nitrendipine / adverse effects,  therapeutic use*
Stroke Volume / drug effects
Treatment Outcome
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Calcium Channel Blockers; 39562-70-4/Nitrendipine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Strategies toward improved control during insulin lispro therapy in IDDM. Importance of basal insuli...
Next Document:  Preservation of physiological responses to hypoglycemia 2 days after antecedent hypoglycemia in pati...