Document Detail

Evaluation of the efficacy and tolerability of nitrendipine in reducing both pressure and left ventricular mass in hypertensive type 2 diabetic patients.
MedLine Citation:
PMID:  9250456     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy and tolerability of nitrendipine in comparison with captopril in hypertensive diabetic patients with left ventricular hypertrophy (LVH). RESEARCH DESIGN AND METHODS: A total of 75 patients enrolled in this study presented stable type 2 diabetes (not treated with insulin) and mild-to-moderate hypertension with a left ventricular mass > or = 75 g/m2 by two-dimensional echocardiography. After a 4-week washout period, 38 patients were assigned to treatment with captopril, and 37 patients to nitrendipine (random allocation). The duration of follow-up was 36 weeks. RESULTS: Patients of both groups were similar with regard to the duration of diabetes and hypertension, systolic and diastolic blood pressure at rest, degree of LVH, metabolic control, and albumin excretion rate (AER). Both drugs were equally effective in reducing systolic and diastolic blood pressure (captopril: from 165 +/- 13/100 +/- 4 to 147 +/- 11/87 +/- 4 mmHg; nitrendipine: from 167 +/- 17/100 +/- 5 to 143 +/- 9/86 +/- 4 mmHg; P < 0.05) and in reversing LVH (nitrendipine: from 87 +/- 2 to 81 +/- 1 g/m2; captopril: from 89 +/- 2 to 85 +/- 2 g/m2; P = 0.0001). Neither the left ventricular end-diastolic volume index nor the left ventricular ejection fraction changed significantly during the treatment period. CONCLUSION: Nitrendipine is as effective as captopril in reducing both systolic and diastolic blood pressure and in reversing LVH. Neither drug showed any negative side effects on fasting plasma glucose and glycated hemoglobin (HbA1c) levels, and both maintain constant AERs.
R Scognamiglio; R Nosadini; M Marin; S Nisti; G Fasoli; M Palisi; F Frigato; F Virgili; A Carraro; G Crepaldi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Diabetes care     Volume:  20     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-15     Completed Date:  1997-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1290-2     Citation Subset:  IM    
Division of Cardiology, Padua University Medical School, Italy.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  therapeutic use
Blood Glucose / metabolism
Blood Pressure / drug effects*
Calcium Channel Blockers / adverse effects,  therapeutic use*
Captopril / adverse effects,  therapeutic use
Diabetes Mellitus, Type 2 / blood,  complications*,  physiopathology
Double-Blind Method
Drug Evaluation
Drug Tolerance
Follow-Up Studies
Hypertension / complications,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / complications,  drug therapy*,  ultrasonography
Middle Aged
Nitrendipine / adverse effects,  therapeutic use*
Stroke Volume / drug effects
Treatment Outcome
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Calcium Channel Blockers; 39562-70-4/Nitrendipine; 62571-86-2/Captopril

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