Document Detail

Evaluation of the efficacy and safety of enalapril plus hydrochlorothiazide plus methyldopa vs standard triple therapy in the treatment of moderate to severe hypertension: results from a multicentre study.
MedLine Citation:
PMID:  2189027     Owner:  NLM     Status:  MEDLINE    
We report the results of a randomized, double-blind, parallel group multicentre study in 120 patients with moderate to severe hypertension, comparing two different types of antihypertensive treatment: a) the standard 'triple therapy' with hydrochlorothiazide, propranolol and hydralazine, and b) the combination of an ACE inhibitor, enalapril with hydrochlorothiazide (HCTZ) and methyldopa. The two regimens caused similar degrees of blood pressure reductions. The only significant difference between the two groups was heart rate due to the bradycardiac effect of propranolol in the group treated with the standard 'triple therapy'. Only 3.4% of patients receiving the regimen of enalapril, HCTZ and methyldopa were withdrawn from the study for adverse reactions, against 10% of patients on HCTZ, propranolol and hydralazine. Four cases of hypokalaemia in the enalapril group and 19 in the propranolol group were reported: so enalapril seemed to ameliorate the hypokalaemic effect of HCTZ. The overall analysis of the study results shows that the treatment based on enalapril, HCTZ and methyldopa is as efficient and better tolerated than the established regimen of HCTZ, propranolol and hydralazine.
G Leonetti; C Cuspidi; L Sampieri; E Ambrosioni; P L Malini; A Pessina; A Semplicini; G Cinotti; S Morabito; A Rappelli
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of human hypertension     Volume:  4     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-07-02     Completed Date:  1990-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Institute of Clinica Medica, University of Milan, Italy.
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MeSH Terms
Blood Pressure / drug effects
Double-Blind Method
Drug Evaluation
Drug Therapy, Combination
Enalapril / administration & dosage*,  adverse effects,  therapeutic use
Heart Rate / drug effects
Hydralazine / administration & dosage,  adverse effects,  therapeutic use
Hydrochlorothiazide / administration & dosage*,  adverse effects,  therapeutic use
Hypertension / drug therapy*
Methyldopa / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Multicenter Studies as Topic
Propranolol / administration & dosage,  adverse effects,  therapeutic use
Randomized Controlled Trials as Topic
Reg. No./Substance:
525-66-6/Propranolol; 555-30-6/Methyldopa; 58-93-5/Hydrochlorothiazide; 75847-73-3/Enalapril; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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