| Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris. | |
| | |
MedLine Citation:
|
PMID: 2190464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The magnitude and duration of the antianginal and anti-ischemic effects of isosorbide mononitrate (IS-5-MN), 20 mg, were determined in 10 patients with chronic stable angina pectoris. An exercise test (treadmill, Bruce protocol) was performed before and at 1, 6, 8 and 10 hours after oral administration of the drug. The patients were randomly assigned to receive IS-5-MN or placebo, and after 1 week of therapy were crossed over to the other formulations. The drug increased the exercise duration from 321 to 455 seconds at 1 hour (p less than 0.001). Time to moderate angina increased from 237 to 324 seconds (p less than 0.05) and time to ST depression greater than or equal to 1 mm increased from 150 to 307 seconds (p less than 0.01) at 1 hour. Placebo had no effect on any of the exercise parameters. Although partially attenuated at 6 hours, the effect of IS-5-MN remained statistically significant even at 8 hours, but not at 10 hours. It is concluded that the duration of action of a single tablet of IS-5-MN, given orally, is 8 hours. |
| | |
Authors:
|
M A de Belder; A Schneeweiss; A J Camm |
Related Documents
:
|
11078284 - Effects of transcendental meditation on symptoms and electrocardiographic changes in pa... 9830234 - Anti-ischemic and anti-anginal effects of controlled-release and conventional isosorbid... 6823854 - Variable threshold exertional angina in patients with transient vasospastic myocardial ... 1575184 - Efficacy of a single dose of slow-release isosorbide dinitrate in the treatment of sile... 15676904 - Effects of exercise on carpal tunnel syndrome symptoms. 18341444 - Effects of training and strenuous exercise on hematologic values and peripheral blood l... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The American journal of cardiology Volume: 65 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1990 Jun |
Date Detail:
|
Created Date: 1990-07-11 Completed Date: 1990-07-11 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 6J-8J Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Angina Pectoris / drug therapy* Clinical Trials as Topic Electrocardiography Exercise Test Humans Isosorbide Dinitrate / pharmacokinetics, therapeutic use* Male Middle Aged Random Allocation Time Factors |
| Chemical | |
Reg. No./Substance:
|
87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intravenous isosorbide-5-mononitrate in the treatment of acute myocardial infarction.
Next Document: Changing dietary patterns.