Document Detail

Evaluation of the efficacy and duration of action of isosorbide mononitrate in angina pectoris.
MedLine Citation:
PMID:  2190464     Owner:  NLM     Status:  MEDLINE    
The magnitude and duration of the antianginal and anti-ischemic effects of isosorbide mononitrate (IS-5-MN), 20 mg, were determined in 10 patients with chronic stable angina pectoris. An exercise test (treadmill, Bruce protocol) was performed before and at 1, 6, 8 and 10 hours after oral administration of the drug. The patients were randomly assigned to receive IS-5-MN or placebo, and after 1 week of therapy were crossed over to the other formulations. The drug increased the exercise duration from 321 to 455 seconds at 1 hour (p less than 0.001). Time to moderate angina increased from 237 to 324 seconds (p less than 0.05) and time to ST depression greater than or equal to 1 mm increased from 150 to 307 seconds (p less than 0.01) at 1 hour. Placebo had no effect on any of the exercise parameters. Although partially attenuated at 6 hours, the effect of IS-5-MN remained statistically significant even at 8 hours, but not at 10 hours. It is concluded that the duration of action of a single tablet of IS-5-MN, given orally, is 8 hours.
M A de Belder; A Schneeweiss; A J Camm
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  65     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6J-8J     Citation Subset:  AIM; IM    
Department of Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom.
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MeSH Terms
Angina Pectoris / drug therapy*
Clinical Trials as Topic
Exercise Test
Isosorbide Dinitrate / pharmacokinetics,  therapeutic use*
Middle Aged
Random Allocation
Time Factors
Reg. No./Substance:
87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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