Document Detail

Evaluation of the effects of toluene inhalation on alveolar epithelial permeability by 99mTc-DTPA inhalation scintigraphy in automobile painters.
MedLine Citation:
PMID:  18049097     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The main component of paint thinner used in industry is toluene diisocyanate (TDI) which can cause occupational asthma in 5-10% of exposed workers. AIM: To investigate the effect of TDI on 99mTc clearance rate of alveolar epithelium and on pulmonary function tests (PFT) in automobile painters, and to determine the relationship between 99mTc-DTPA radioaerosol lung scintigraphy and serum levels of antioxidant enzymes and metalloproteinases (MMPs) of automobile painters. METHODS: Twenty-eight automobile painters and 13 control subjects were included in the study. 99mTc-DTPA aerosol inhalation scintigraphy and PFT were administered to all subjects. Clearance half-time (T1/2) and penetration index (PI) on the first-minute image after 99mTc-DTPA scintigraphy were calculated. Blood levels of MDA, antioxidant enzymes and metalloproteinases were measured. RESULTS: The mean T1/2 values of automobile painters were longer in both smoker and non-smoker subjects, but the difference was not significant (P>0.05). Although the PFT values decreased in automobile painters, there was no significant difference between each group. Any correlation between spirometric measurements and T1/2 or PI values in non-smoking automobile painters was not detected. Negative correlation among mean T1/2 value and FVC% and FEV1% in smoking automobile painters, and positive correlation between mean T1/2 value and MMP-9, GSH-Px levels in non-smoking automobile painters were detected. CONCLUSION: Our results suggested that the clearance of 99mTc-DTPA from the lungs of automobile painters was slower than in the control group, but the difference is not statistically significant. This data also supports the observation that TDI occasionally stimulates bronchial changes rather than alveolar changes in automobile painters.
Sevim Sureyya Cerci; Onder Ozturk; Recep Sutcu; Feride Meltem Ozbek; Cetin Lutfi Baydar; Mustafa Yildiz; Ahmet Akkaya; Namk Delibas
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  29     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  45-52     Citation Subset:  IM    
Department of Nuclear Medicine, Suleyman Demirel University, Isparta, Turkey.
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MeSH Terms
Administration, Inhalation
Pulmonary Alveoli / drug effects,  metabolism*,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Respiratory Mucosa / drug effects,  metabolism*,  radionuclide imaging*
Technetium Tc 99m Pentetate / diagnostic use*,  pharmacokinetics*
Toluene / administration & dosage*
Reg. No./Substance:
0/Radiopharmaceuticals; 108-88-3/Toluene; 65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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