Document Detail


Evaluation of the effects of pulse high-volume hemofiltration in patients with severe sepsis: a preliminary study.
MedLine Citation:
PMID:  20872345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to evaluate the effects of pulse high-volume hemofiltration (PHVHF) in patients with severe sepsis.
METHODS: Twenty-two patients with severe sepsis admitted to XiJing hospital between January 2009 and January 2010 were included in the present study. Patients were randomly divided into the control group (conventional treatment) and the PHVHF group. Patients in the PHVHF group received 72 h of PHVHF treatment in addition to conventional treatment after admission. PHVHF was conducted as follows: HVHF 85 ml/kg per hour for 6 h followed by continuous venovenous hemofiltration 35 ml/kg per hour for 18 h with an AN69 membrane. The hemofilter was replaced every 24 h and PHVHF was performed with 250 to 300 ml/min blood flow rate. The blood samples were taken to measure the changes of plasma cytokines (TNF-α, IL-1, IL-4, IL-6 and IL-10).
RESULTS: With 72 h of PHVHF treatment, there was an improvement in clinical features and hemodynamics variables in PHVHF-treated patients. All plasma cytokines after PHVHF treatment were significantly lower than those at the start of PHVHF treatment (p<0.05). In contrast, there was no significant change in control patients.
CONCLUSIONS: Our findings suggest that PHVHF is a feasible adjuvant modality in the treatment of patients with severe sepsis. With the application of PHVHF treatment, plasma cytokines are effectively removed. Considering the lower cost and better feasibility than continuous high-volume hemofiltration (CHVF), PHVHF shows promising prospects for the future.
Authors:
Zhang Peng; Peng Pai; Wang Han-Min; Zhu Jun; Liu Hong-Bao; Li Rong; Huang Chen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  33     ISSN:  1724-6040     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  505-11     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi province, China. zhangpeng@fmmu.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Adult
China
Down-Regulation
Female
Hemodynamics
Hemofiltration / methods*
Humans
Interleukins / blood
Male
Middle Aged
Pilot Projects
Sepsis / immunology,  physiopathology,  therapy*
Severity of Illness Index
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha / blood
Chemical
Reg. No./Substance:
0/Interleukins; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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