Document Detail

Evaluation of the effects of lymph drainage by a thoracic duct fistula in experimental peritonitis.
MedLine Citation:
PMID:  3188792     Owner:  NLM     Status:  MEDLINE    
Previous studies suggest that systemic endotoxemia in peritonitis is mainly related to lymphatic transport via the thoracic duct. Rats with fecal peritonitis but with or without a lymph draining thoracic duct fistula were studied with reference to the concentrations of endogenously produced endotoxin in arterial plasma, hemodynamic parameters, organ blood flow, blood corpuscle parameters, glucose and lactate metabolism and survival. Lymph drainage significantly reduced the endotoxin concentrations in arterial plasma, but did not totally prevent systemic endotoxemia, and was related to maintained total peripheral vascular resistance. On the other hand, peritonitic rats without lymph drainage, and consequently higher endotoxin concentrations, had a significant fall in vascular resistance combined with a compensatory rise in cardiac output. Lymph drainage also contributed to a smaller decrease of platelet and leucocyte counts while no effect was observed on glucose metabolism. Despite the effect of lymph drainage on hemodynamic and hematologic responses no effect on survival time was recorded.
P Olofsson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  154     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1988-12-16     Completed Date:  1988-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  453-9     Citation Subset:  IM    
Department of General Surgery, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Blood Glucose / analysis
Endotoxins / blood*
Fistula / blood*,  physiopathology
Hemoglobins / analysis
Lymph / physiology*
Peritonitis / blood*,  physiopathology
Rats, Inbred Strains
Thoracic Duct / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Endotoxins; 0/Hemoglobins

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