| Evaluation of the effects of lymph drainage by a thoracic duct fistula in experimental peritonitis. | |
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MedLine Citation:
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PMID: 3188792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies suggest that systemic endotoxemia in peritonitis is mainly related to lymphatic transport via the thoracic duct. Rats with fecal peritonitis but with or without a lymph draining thoracic duct fistula were studied with reference to the concentrations of endogenously produced endotoxin in arterial plasma, hemodynamic parameters, organ blood flow, blood corpuscle parameters, glucose and lactate metabolism and survival. Lymph drainage significantly reduced the endotoxin concentrations in arterial plasma, but did not totally prevent systemic endotoxemia, and was related to maintained total peripheral vascular resistance. On the other hand, peritonitic rats without lymph drainage, and consequently higher endotoxin concentrations, had a significant fall in vascular resistance combined with a compensatory rise in cardiac output. Lymph drainage also contributed to a smaller decrease of platelet and leucocyte counts while no effect was observed on glucose metabolism. Despite the effect of lymph drainage on hemodynamic and hematologic responses no effect on survival time was recorded. |
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Authors:
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P Olofsson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta chirurgica Scandinavica Volume: 154 ISSN: 0001-5482 ISO Abbreviation: Acta Chir Scand Publication Date: 1988 Jul-Aug |
Date Detail:
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Created Date: 1988-12-16 Completed Date: 1988-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906530 Medline TA: Acta Chir Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 453-9 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Drainage Endotoxins / blood* Fistula / blood*, physiopathology Hematocrit Hemodynamics Hemoglobins / analysis Lymph / physiology* Male Peritonitis / blood*, physiopathology Prognosis Rats Rats, Inbred Strains Thoracic Duct / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Endotoxins; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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