Document Detail

Evaluation of the effects of ischemic preconditioning with a short reperfusion phase on patients undergoing a coronary artery bypass graft.
MedLine Citation:
PMID:  21057441     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was conducted to evaluate the effects of ischemic preconditioning (IP) with a short period of reperfusion (2 min) during brief ischemic preconditioning (6 min) on patients undergoing coronary artery bypass grafting (CABG).
METHODS: In a randomized controlled trial, 40 patients undergoing on-pump CABG with cold blood cardioplegia were allocated into two groups, one IP and one control. IP was induced by 2 cycles of ascending aorta clamping (2 min for each) followed by two reperfusion phases (1 min for each). Left ventricular ejection fraction (LVEF) was measured before and after surgery. Creatine phosphokinase (CK) and CK-MB were measured 12 hrs before surgery, immediately after aortic clamping, and 24 hrs after CABG. Postoperative myocardial infarction (MI), ventricular arrhythmia, duration of inotropic support, and hemodynamic parameters were also noted.
RESULTS: More patients in the control group needed inotropic support (65% vs. 40%, P<0.05). Moreover, duration of inotropic support was longer in the control group (9 ± 1.2 vs. 3.8 ± 1.4 hrs, P<0.05). There were no significant differences between two groups regarding development of ventricular arrhythmia, MI, values of CK, CK-MB, and postoperative LVEF. No patient needed an intra-aortic balloon pump, and no deaths occurred.
CONCLUSION: A short period of reperfusion phase declined post-CABG inotrope requirements; however, it did not reduce the cardiac enzymes. Our results suggested that reperfusion should be longer than 2 min to be capable of reducing cardiac enzymes.
Mohammad Jebeli; Hamid Reza Esmaili; Mohammad Hussein Mandegar; Mohammad R Rasouli; Payam Eghtesadi-Araghi; Robabeh Mohammadzadeh; Ali Darehzereshki; Saied Dianat
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  16     ISSN:  2186-1005     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-04-21     Revised Date:  2012-06-18    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Department of Cardiac Surgery, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Coronary Artery Bypass*
Heart Arrest, Induced
Ischemic Preconditioning, Myocardial / methods*
Middle Aged
Myocardial Reperfusion*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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