Document Detail


Evaluation of effectiveness of iron-folate supplementation and anthelminthic therapy against anemia in pregnancy--a study in the plantation sector of Sri Lanka.
MedLine Citation:
PMID:  8030609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intervention measures against anemia available to plantation workers during pregnancy include fortified food supplements (thriposha) and iron-folate supplements containing 60 mg elemental Fe. The effectiveness of these intervention measures was studied in 195 subjects whose iron and nutritional status were assessed at < 24 and > 32 wk of gestation. Taking thriposha conferred no significant benefit on maternal nutritional status, probably because sufficient amounts were not consumed. An increase in the duration of iron-folate supplementation to > 17 wk caused a significant positive change (P < 0.01) in hemoglobin, whereas an increase in the dose frequency had no significant benefit. Anthelminthic therapy in addition to iron-folate supplements caused a significant positive change in hemoglobin (P < 0.001) and serum ferritin (P < 0.005) compared with no supplementation. Thus, anthelminthic therapy significantly increased the beneficial effects of iron supplementation on hemoglobin concentration and iron status.
Authors:
T M Atukorala; L D de Silva; W H Dechering; T S Dassenaeike; R S Perera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  60     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-11     Completed Date:  1994-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  286-92     Citation Subset:  AIM; IM    
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Colombo, Sri Lanka.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / etiology,  prevention & control*
Anthelmintics / therapeutic use*
Body Mass Index
Drug Combinations
Drug Therapy, Combination
Female
Folic Acid / administration & dosage,  adverse effects,  therapeutic use*
Follow-Up Studies
Food, Fortified
Hemoglobins / analysis
Humans
Iron / administration & dosage,  adverse effects,  therapeutic use*
Nutritional Status
Pregnancy
Pregnancy Complications / etiology,  prevention & control*
Pregnancy Complications, Parasitic / drug therapy
Protoporphyrins / blood
Sri Lanka
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Drug Combinations; 0/Hemoglobins; 0/Protoporphyrins; 59-30-3/Folic Acid; 7439-89-6/Iron
Comments/Corrections
Comment In:
Am J Clin Nutr. 1995 Nov;62(5):1023-4   [PMID:  7572729 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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