Document Detail

Evaluation of the effect of trimetazidine on Tc-99m methoxyisobutyl isonitrile gated scintigraphy in patients with coronary artery ectasia.
MedLine Citation:
PMID:  16228058     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Coronary artery ectasia (CAE) is the abnormal dilatation of a segment of the coronary artery to a diameter of at least 1.5 times that of normal adjacent segments. Symptoms are variable, and its prognosis and treatment modalities are unclear. The aim of this study is to evaluate the effect of trimetazidine (TMZ) on ischemic left ventricular function by rest-stress Tc-99m methoxyisobutyl isonitrile (Tc-99m MIBI) myocardial scintigraphy in symptomatic patients with CAE. METHODS: We included patients with ectasia admitted to our Cardiology Department, Turkey, between 2003 and 2004 in this study. All patients underwent coronary angiography and diagnosed with CAE, before and 4 weeks after TMZ administration. Seventeen patients (9 men, 8 women) underwent gated single-proton emission tomographic (SPECT) using Tc-99m MIBI. We performed quantitative global and regional ventricular functional analysis using quantitative gated SPECT software. RESULTS: The global ejection fraction increased from 59.9%+/-8.9% to 62.6%+/-8.3% after therapy (p=0.033). In addition, the end systolic volume and the end diastolic volume decreased after therapy (101.7+/-23.5 ml to 95.1+/-22.9 ml, p=0.002; from 41.1+/-14.3 to 36.4+/-13.6, p=002). In all segments, we observed significant post-therapy increases in relative tracer uptake. Percentage of MIBI uptake was 71.2+/-15.3 at baseline stress and 73.2+/-15 post-TMZ (p=0.001). As global function parameters, the total wall motion normal areas changed significantly (67-74% p=0.01) after therapy, but the total wall thickness did not changed significantly(49-45%, p=0.21). CONCLUSION: The results of this study demonstrate that TMZ improves myocardial function by rest-stress Tc-99m MIBI gated SPECT during stress-induced ischemia in patients with CAE. Also, the outcomes revealed improvement in functional parameters, and percentage of MIBI uptake post TMZ administration. We can use this procedure to monitor the effect of TMZ in CAE patients.
Berna Okudan; Feride M Ozbek; Abdullah Dogan; Begum Ozturk; Mustafa Yildiz
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  26     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-03-28     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1573-8     Citation Subset:  IM    
Department of Nuclear Medicine, School of Medicine, Suleyman Demirel University, Istanbul, Turkey.
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MeSH Terms
Age Factors
Cohort Studies
Coronary Disease / drug therapy*,  pathology,  radionuclide imaging*
Dilatation, Pathologic / drug therapy,  radionuclide imaging*
Heart Function Tests
Middle Aged
Risk Assessment
Severity of Illness Index
Sex Factors
Technetium Tc 99m Sestamibi / diagnostic use*
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Trimetazidine / therapeutic use*
Ventricular Function, Left / drug effects
Reg. No./Substance:
109581-73-9/Technetium Tc 99m Sestamibi; 5011-34-7/Trimetazidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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