Document Detail


Evaluation of the effect of tacrolimus-loaded liquid crystalline nanoparticles on psoriasis-like skin inflammation.
MedLine Citation:
PMID:  23210668     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Psoriasis is a chronic relapsing inflammatory skin disorder affecting 2-3 % of world population. In present context, a novel topical formulation that could deliver tacrolimus effectively for psoriasis treatment would be of great interest. Liquid crystalline nanoparticle (LCN) is one of the potential drug delivery systems for topical drug delivery. Herein, we studied the effects of tacrolimus-loaded LCNs on in vitro skin permeation and retention as well as on in vivo psoriasis-like skin inflammation. Characterization of nanoparticles included particle size and entrapment efficiency analysis that presented nanoparticles of 149.1 nm for monoolein-based and 204.3 nm for oleic acid added monoolein-based nanoparticles with entrapment efficiency of tacrolimus above 99 %. Skin permeation and retention study revealed a significant increase in the amount of tacrolimus permeated and retented by the use of LCNs. Tacrolimus-loaded LCNs were more effective in the treatment of psoriasis-like skin inflammation as compared to tacrolimus dissolved in propylene glycol. Hence, this study provides a basis for possible applicability of tacrolimus-loaded LCNs in the treatment of psoriasis.
Authors:
Raj Kumar Thapa; Bong Kyu Yoo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
College of Pharmacy, Yeungnam University , 214-1 Dae-dong, Kyungsan 712-749 , South Korea.
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