| Evaluation of the effect of intravenous volume expanders upon the volume of distribution of gentamicin in septic neonates. | |
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MedLine Citation:
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PMID: 19544484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sepsis has been reported to increase the volume of distribution of gentamicin in neonates. To determine whether this was caused by the use of intravenous volume expanders a retrospective nested case-control study was performed comparing confirmed septic neonates with non-septic controls. Data were collected on intravenous administration of 0.45% saline/10% dextrose, 0.45% saline/5% dextrose, 0.9% normal saline, red blood cells, platelets, immunoglobulin (Intragam P) and albumin. A population pharmacokinetic analysis was performed using NONMEM for 116 neonates (29 confirmed septic) from which 363 gentamicin serum concentrations were available. The final covariate model was CL=0.097x(current weight/2)(1.3)x(postnatal age/7)(0.29) and V=1.07x(current weight/2)(0.8)+(confirmed sepsis)x0.13. The gentamicin volume of distribution was not significantly influenced by the cumulative intravenous volume expanders. The principal covariates that affected the gentamicin volume of distribution were current body weight and confirmed sepsis. |
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Authors:
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Catherine M T Sherwin; Esther Kostan; Roland S Broadbent; Natalie J Medlicott; David M Reith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 30 ISSN: 1099-081X ISO Abbreviation: Biopharm Drug Dispos Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-02 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: England |
Other Details:
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Languages: eng Pagination: 276-80 Citation Subset: IM |
Copyright Information:
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Copyright 2009 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Women's and Children's Health, Dunedin School of Medicine, Dunedin, New Zealand. Catherine.Sherwin@cchmc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anti-Bacterial Agents / pharmacokinetics* Case-Control Studies Drug Interactions Female Gentamicins / pharmacokinetics* Humans Infant, Newborn Male Plasma Substitutes / pharmacology* Retrospective Studies Sepsis / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Gentamicins; 0/Plasma Substitutes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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