Document Detail


Evaluation of dynamic headspace with gas chromatography/mass spectrometry for the determination of 1,1,1-trichloroethane, trichloroethanol, and trichloroacetic acid in biological samples.
MedLine Citation:
PMID:  15686993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A sensitive and reproducible method is described for the analysis of trichloroacetic acid in urine and 1,1,1-trichloroethane in blood using dynamic headspace GC/MS. Samples were analyzed using the soil module of a modified purge and trap autosampler to facilitate the use of disposable purging vessels. Coefficients of variation were below 3.5% for both analytes, and response was linear in the range of 0.01-7.0 microg/ml for trichloroacetic acid and 0.9 ng/ml-2.2 microg/ml for 1,1,1-trichloroethane. Attempts at using dynamic headspace for the analysis of trichloroethanol in urine were unsuccessful.
Authors:
Douglas O Johns; Russell L Dills; Michael S Morgan
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  817     ISSN:  1570-0232     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-02     Completed Date:  2005-09-01     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195-7234, USA. djohns@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Ethylene Chlorohydrin / analogs & derivatives*,  analysis,  blood,  urine
Gas Chromatography-Mass Spectrometry / methods*
Humans
Trichloroacetic Acid / analysis*,  blood,  urine
Trichloroethanes / analysis*,  blood,  urine
Grant Support
ID/Acronym/Agency:
P42 ES04696/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Trichloroethanes; 107-07-3/Ethylene Chlorohydrin; 113C650IR1/1,1,1-trichloroethane; 76-03-9/Trichloroacetic Acid; AW835AJ62N/2,2,2-trichloroethanol

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