Document Detail

Evaluation of dual-energy X-ray absorptiometry for body-composition assessment in piglets and term human neonates.
MedLine Citation:
PMID:  8561054     Owner:  NLM     Status:  MEDLINE    
The reproducibility, accuracy, and precision of dual-energy X-ray absorptiometry (DXA) was assessed by scanning 13 piglets (1471-5507 g) in triplicate. In four piglets, fat content was increased with porcine lard around the abdomen; additional measurements were performed on these animals. Reproducibility in DXA measurements from the animals without added fat was 0.09% for body weight, 1.95% for bone mineral content (BMC), and 5.35% for fat content. DXA estimates of body weight, BMC, and fat content were significantly correlated with scale body weight, ash weight, chemical calcium, and chemical fat. Body weight was measured accurately but fat content was overestimated by DXA. Mean BMC estimated by DXA represented 48% of ash weight and 215% of calcium content. The precision of DXA was 0.23% for body weight, 10.99% for ash weight, and 4.44% for calcium content. The precision of DXA for fat content was poor. However, for measurements performed in piglets with > 250 g fat, the precision was 8.85%. Thirty appropriate-forgestational-age term human neonates (birth weight: 3188 +/- 217 g) were scanned once during the first week of life. BMC and fat content were 54 +/- 6 and 470 +/- 92 g, respectively, which corresponded to 26.4 +/- 2.6 g calcium and 427 +/- 82 g fat. These were close to the reference values previously determined by chemical analysis. This study suggests that DXA is accurate and reliable for measurement of calcium and fat contents in human neonates. Further refinements would be beneficial for determining fat content in preterm human infants.
J C Picaud; J Rigo; K Nyamugabo; J Milet; J Senterre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  63     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-02-26     Completed Date:  1996-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  AIM; IM    
Department of Neonatology, University of Liège, Belgium.
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MeSH Terms
Absorptiometry, Photon / standards*
Adipose Tissue / chemistry
Animals, Newborn
Body Composition*
Body Weight
Bone Density
Bone and Bones / chemistry
Calcium / analysis
Evaluation Studies as Topic
Gestational Age
Infant, Newborn
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry, Atomic
Reg. No./Substance:

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