| Evaluation of drug therapy for treatment of hypertensive urgencies in the emergency department. | |
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MedLine Citation:
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PMID: 1994934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oral nifedipine (N) and clonidine (C) are often used in the treatment of hypertensive urgencies; however, until recently, there were no comparative studies using the same patient population. The authors reviewed the records of hypertensive patients treated in the emergency department between October 1, 1987 and September 30, 1988. Selected patients had a diastolic blood pressure (DBP) of greater than 115 mm Hg without evidence of acute end organ damage. Patients were stratified into three treatment groups: N, C, and group 3 (G3). G3 received a variety of drug therapies but not exclusively N or C. Systolic blood pressure (SBP), DBP, mean arterial pressure (MAP), percent decrease in MAP (%MAP), time to lower blood pressure, admissions, and discharges were evaluated. Efficacy and safety were defined as reaching a DBP less than 110 mm Hg but %MAP of no greater than either 25% or 40%, respectively. Thirty-five N, 32 C, and 27 G3 patients were identified with no statistical difference between groups in race, gender, pretreatment SBP, DBP, or MAP. N, C, and G3 significantly reduced SBP, DBP, and MAP (P less than .01). Comparing N, C, and G3, no differences were observed in %MAP, admissions, discharges, efficacy, or safety. Time required to decrease blood pressure differed between all three groups (44 +/- 32 N v 77 +/- 57 C v 152 +/- 94 min G3) (p less than .05). These results indicate that N, C, and a variety of drug therapies are equally effective and safe in the treatment of hypertensive urgencies. |
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Authors:
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V L Just; B J Schrader; F P Paloucek; T J Hoon; J B Leikin; J L Bauman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 9 ISSN: 0735-6757 ISO Abbreviation: Am J Emerg Med Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-03-28 Completed Date: 1991-03-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice, University of Illinois, Chicago 60612. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Pressure / drug effects Clonidine / administration & dosage, pharmacology, therapeutic use* Drug Therapy / standards*, statistics & numerical data Emergency Service, Hospital* Evaluation Studies as Topic Female Hospitals, University Humans Hypertension / diagnosis, drug therapy*, epidemiology Illinois / epidemiology Male Middle Aged Nifedipine / administration & dosage, pharmacology, therapeutic use* Patient Compliance Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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