Document Detail


Evaluation of drug release kinetics and physico-chemical characteristics of metronidazole floating beads based on calcium silicate and gas-forming agents.
MedLine Citation:
PMID:  19694496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present investigation metronidazole-loaded alginate beads consisting of calcium silicate as a porous carrier or NaHCO(3) as a gas-forming agent were prepared for local eradication of Helicobacter Pylori. Gelation method was used for preparation of conventional sodium alginate beads. Drug entrapment efficiency, drug loading, floating properties, drug release, crystallinity and release kinetic as well as morphology of the prepared beads were assessed. The silicate based beads showed slower release pattern, compared to the gas-forming beads due to network structure strengthening effect of the calcium silicate. Furthermore, the gas-forming-based beads had shorter initial buoyancy lag time, owing to the fact that the NaHCO(3) produced larger pores than those of silicate treated ones. Drug entrapment efficiency ranged between 61.7 and 93.1% for the prepared formulations. The maximum value of drug loading for gas-forming and silicate-based beads were 66.64% and 34.97%, respectively. Kinetically, release pattern of metronidazole in simulated gastric fluid from the beads fitted best to Reciprocal powered time, Weibull and log-probability models with the respect overall mean percentage error values of 4.50, 5.30 and 7.76. By and large, these systems can float in the gastric condition and control the drug release from the beads.
Authors:
Yousef Javadzadeh; Sanaz Hamedeyazdan; Khosro Adibkia; Farhad Kiafar; Mohammad Hosein Zarrintan; Mohammad Barzegar-Jalali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  15     ISSN:  1097-9867     ISO Abbreviation:  Pharm Dev Technol     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  329-38     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy and Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. javadzadehy@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Alginates / chemistry
Anti-Infective Agents / administration & dosage*,  chemistry
Calcium Compounds / chemistry*
Crystallization
Delayed-Action Preparations
Drug Carriers / chemistry*
Drug Delivery Systems
Glucuronic Acid / chemistry
Helicobacter Infections / drug therapy
Helicobacter pylori / drug effects
Hexuronic Acids / chemistry
Kinetics
Metronidazole / administration & dosage*,  chemistry
Silicates / chemistry*
Sodium Bicarbonate / chemistry
Chemical
Reg. No./Substance:
0/Alginates; 0/Anti-Infective Agents; 0/Calcium Compounds; 0/Delayed-Action Preparations; 0/Drug Carriers; 0/Hexuronic Acids; 0/Silicates; 1344-95-2/calcium silicate; 144-55-8/Sodium Bicarbonate; 443-48-1/Metronidazole; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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