| Evaluation of the dose-effect relationship of a new ace inhibitor (perindopril) by an automatic blood pressure recorder. | |
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MedLine Citation:
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PMID: 3061819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Repeated blood pressure recordings by non-invasive devices are of better predictive value than single measurements in the evaluation of antihypertensive treatment. Such a method has been used to establish the dose-effect relationship of perindopril. After a two-week placebo run-in period, 40 patients with essential hypertension (age 56.6 +/- 1.5 years, 31 males, nine females) were treated with placebo or 2, 4 or 8 mg of perindopril once daily for one month following a randomized double-blind design. They were included if at least 75% of diastolic blood pressure recordings, made over an 8 h diurnal period using an automatic blood pressure recorder, were greater than 95 mmHg on placebo. Values (mean +/- SEM) before and after treatment were assessed using analysis of variance. These data showed a significantly greater reduction of blood pressure with 4 mg and 8 mg daily doses compared to placebo and the 2 mg daily dose. Such results were not obtained with blood pressure levels recorded by a mercury sphygmomanometer, confirming the value of an automatic blood pressure recorder as a tool in therapeutic trials. |
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Authors:
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R Luccioni; Y Frances; R Gass; C Schwab; J P Santoni; L Perret |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European heart journal Volume: 9 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-02-10 Completed Date: 1989-02-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1131-6 Citation Subset: IM |
Affiliation:
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Service de Médecine Interne, Urgences C.H.U. Nord, Marseille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin-Converting Enzyme Inhibitors / administration & dosage* Antihypertensive Agents / administration & dosage* Blood Pressure / drug effects Blood Pressure Determination / instrumentation* Clinical Trials as Topic Dose-Response Relationship, Drug Double-Blind Method Female Humans Hypertension / drug therapy* Indoles / administration & dosage* Male Middle Aged Perindopril Random Allocation Signal Processing, Computer-Assisted* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Indoles; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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