| Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans. | |
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MedLine Citation:
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PMID: 10543468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pilot studies suggest positron emission tomography (PET) scanning may be superior to conventional imaging in staging esophageal cancer, especially in the detection of radiographically occult distant metastases. This report summarizes our experience with PET in staging esophageal cancer. METHODS: One hundred consecutive PET scans in 91 patients with esophageal cancer referred for surgery were prospectively collected (1995 to 1998) and compared with computerized tomography (CT) and bone scan. PET images were acquired after injection of 18F-fluorodeoxyglucose and evaluated for abnormal uptake. Minimally invasive surgical staging (MIS) and/or clinical correlation were used to confirm or refute imaging results. RESULTS: MIS or clinical correlation confirmed 70 distant metastases in 39 cases. PET detected 51 metastases in 27 of 39 cases (69% sensitivity, 93.4% specificity, 84% accuracy) compared with CT, which detected 26 metastases in 18 of 39 cases (46.1% sensitivity, 73.8% specificity, 63% accuracy) (p < 0.01). CONCLUSIONS: PET was more accurate than CT in detecting distant metastases, but was only 69% sensitive compared with minimally invasive staging. |
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Authors:
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J D Luketich; D M Friedman; T L Weigel; M A Meehan; R J Keenan; D W Townsend; C C Meltzer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 68 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-09 Completed Date: 1999-11-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1133-6; discussion 1136-7 Citation Subset: AIM; IM |
Affiliation:
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Section of Thoracic Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA. luketichjd@msx.upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology,
radionuclide imaging,
secondary*,
surgery Adult Aged Aged, 80 and over Esophageal Neoplasms / pathology, radionuclide imaging*, surgery Female Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Neoplasm Metastasis Neoplasm Staging Sensitivity and Specificity Surgical Procedures, Minimally Invasive Tomography, Emission-Computed* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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