| Evaluation of digital and laminar blood flow in horses given a low dose of endotoxin. | |
| | |
MedLine Citation:
|
PMID: 9492935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To measure blood flow in the palmar digital artery and laminae corium, using ultrasonic and laser Doppler flowmetry, respectively. ANIMALS: 6 healthy horses. PROCEDURE: Digital blood flow and laminar perfusion, respectively, were measured by placing a flow probe around the palmar digital artery and a laser Doppler flow probe in a hole in the dorsal aspect of the hoof wall. All horses were given saline (0.9% NaCl) solution (1 L, IV, during a 30-minute period). Seven days later, each horse was given endotoxin (0.1 microgram/kg of body weight, IV, in 1 L of saline solution, during a 30-minute period). Digital blood flow, laminar perfusion, heart and respiratory rates, body temperature, and clinical signs of endotoxemia were recorded throughout a 240-minute period. Repeated-measures ANCOVA was used to evaluate changes in outcome variables. RESULTS: Treatment with saline solution did not cause a change in measured variables. All horses had mild clinical signs of endotoxemia. Endotoxin treatment caused a significant decrease in digital blood flow and increases in heart rate and body temperature. Laminar perfusion decreased after endotoxin treatment. CONCLUSIONS: Endotoxin administration caused a profound transient decrease in digital blood flow and a less substantial decrease in laminar perfusion. CLINICAL RELEVANCE: Horses with clinical endotoxemia were likely to have decreased digital blood flow and possibly, decreased laminar perfusion, potentially predisposing them to vascular alterations within the digits. |
| | |
Authors:
|
J E Ingle-Fehr; G M Baxter |
Related Documents
:
|
2932685 - Noninvasive doppler flowmetry for measuring regional blood flow. 2954015 - Drug-induced alterations in cochlear blood flow as recorded by the laser doppler flowme... 1833995 - Effect of orthodontic forces on blood flow in human gingiva. 10335775 - Intracardiac doppler hemodynamics and flow: new vector, phased-array ultrasound-tipped ... 2433785 - D-phe-pro-arg-chloromethylketone: its potential use in inhibiting the formation of in v... 21618935 - Who needs autologous blood donation in joint replacement? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: American journal of veterinary research Volume: 59 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1998 Feb |
Date Detail:
|
Created Date: 1998-04-07 Completed Date: 1998-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 192-6 Citation Subset: IM |
Affiliation:
|
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State Univesity, Fort Collins 80523, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Flow Velocity / drug effects* Endotoxemia / physiopathology* Endotoxins / toxicity* Female Forelimb / blood supply* Heart Rate Horse Diseases* Horses Laser-Doppler Flowmetry Male Orchiectomy Toes / blood supply* |
| Chemical | |
Reg. No./Substance:
|
0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of endotoxin on hormonal responses to thyrotropin and thyrotropin-releasing hormone in dogs.
Next Document: Effect of different full-limb casts on in vitro bone strain in the distal portion of the equine fore...