Document Detail

Evaluation of dialyzers used in shortened dialysis.
MedLine Citation:
PMID:  2688714     Owner:  NLM     Status:  MEDLINE    
The clearance of urea and beta 2-microglobulin are important considerations along with biocompatibility in selecting membranes for use in shortened dialysis. During 3 hr of dialysis we have measured the in vivo urea clearances, pre- and post-beta 2-M levels, plasma clearance and simultaneous dialysance of beta 2-M. Leucopenia was compared after 15 min of dialysis on a cellulose acetate (CA) dialyzer and a polyacrylonitrile dialyzer (PAN). Clearance of urea was similar in both dialyzers. In contrast to CA, PAN removed beta 2-M and exhibited minimal leucopenia. The dialysance of beta 2-M was significantly less than the simultaneous blood side clearance. The disparity between blood clearance and dialysance by PAN membranes suggests removal of beta 2-M by adsorption and diffusion. We conclude that in comparison with CA dialyzers, PAN membranes remove beta 2-M, have equivalent urea clearances, and are more biocompatible.
J Petersen; K D Ramsey; M S Kang; I T Yeh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  ASAIO transactions / American Society for Artificial Internal Organs     Volume:  35     ISSN:  0889-7190     ISO Abbreviation:  ASAIO Trans     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8611947     Medline TA:  ASAIO Trans     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-40     Citation Subset:  IM    
Division of Nephrology, Stanford University, California.
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MeSH Terms
Acrylic Resins*
Cellulose / analogs & derivatives*
Kidney Failure, Chronic / blood,  therapy*
Kidney, Artificial*
Leukocyte Count
Membranes, Artificial*
Metabolic Clearance Rate
Urea / blood*
beta 2-Microglobulin / metabolism*
Reg. No./Substance:
0/Acrylic Resins; 0/Membranes, Artificial; 0/beta 2-Microglobulin; 25014-41-9/polyacrylonitrile; 57-13-6/Urea; 9004-34-6/Cellulose; 9004-35-7/acetylcellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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