Document Detail

Evaluation of the diagnostic performance of fibrin monomer in disseminated intravascular coagulation.
MedLine Citation:
PMID:  21779185     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fibrin-related markers (FRM) such as fibrin monomer (FM) and D-dimer (DD) are considered useful biological markers for the diagnosis of disseminated intravascular coagulation (DIC). However, no studies on the diagnostic performance of different FRMs have been published in Korea. The aim of this study was to evaluate the diagnostic performance of FM for DIC in comparison with DD.
METHODS: The reference limit of FM was determined based on plasma sample data obtained from 210 control individuals. To evaluate diagnostic performance, FM data from the plasma samples of 139 patients with DIC-associated diseases were obtained for DIC scoring. FM was measured by immunoturbidimetry using STA-LIATEST FM (Diagnostica Stago, France). Patients were classified according to the DIC score as non-DIC, non-overt DIC, or overt DIC. ROC curve analyses were performed.
RESULTS: The reference limit in the control individuals was determined to be 7.80 µg/mL. Patients with DIC-associated diseases were categorized as non-DIC (N=43), non-overt DIC (N=80), and overt DIC (N=16). ROC curve analyses showed that the diagnostic performance of FM was comparable to DD in both non-overt DIC and overt DIC (P=0.596 and 0.553, respectively). In addition, FM had higher sensitivity, specificity, positive predictive value, and negative predictive value than DD for differentiating overt DIC from non-DIC.
CONCLUSIONS: This study demonstrated that the diagnostic performance of FM for DIC was comparable to DD. FM might be more sensitive and more specific than DD in the diagnosis of overt DIC, but not non-overt DIC.
Kyoung-Jin Park; Eui-Hoon Kwon; Hee-Jin Kim; Sun-Hee Kim
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2011-06-28
Journal Detail:
Title:  The Korean journal of laboratory medicine     Volume:  31     ISSN:  1598-6535     ISO Abbreviation:  Korean J Lab Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-22     Completed Date:  2011-12-01     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101322822     Medline TA:  Korean J Lab Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
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MeSH Terms
Area Under Curve
Biological Markers / blood
Disseminated Intravascular Coagulation / blood,  diagnosis*
Fibrin Fibrinogen Degradation Products / analysis*,  immunology,  standards
Immunoassay / methods*,  standards
Nephelometry and Turbidimetry / methods*,  standards
ROC Curve
Reagent Kits, Diagnostic
Reference Values
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/Reagent Kits, Diagnostic; 0/fibrin fragment D; 0/fibrinmonomer

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