Document Detail


Evaluation of the developmental toxicity of artemether during different phases of rat pregnancy.
MedLine Citation:
PMID:  19332101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present investigation was performed to examine the effect of artemether on rat pregnancy and embryonic/fetal development during different phases of pregnancy. Artemether was administered orally to Wistar rats at doses 3.5 and 7 mg/kg during blastogenesis, organogenesis and fetal period. When administered during blastogenesis, the preimplantation loss, number of implantations, resorptions, living fetuses, external and skeletal examination did not differ from those of control, however the higher dose induced reduction in fetal body weight and caused pre-term delivery in 3 of 10 pregnant rats. During organogenesis complete fetal resorption was observed in all dams treated with the higher dose, while in the lower dose 32% of implants were resorbed and live fetuses showed decreased fetal weight with low incidence of skeletal retardation. Artemether did not adversely affect prenatal development in rats treated during the fetal period although the higher dose level induced reduction in fetal body weight. In conclusion, no evidence of maternal toxicity, artemether was embryolethal at 3.5 and 7 mg/kg when dosed during organogenesis, the surviving fetuses showed fetal growth retardation without incidence of malformations, treatment during blastogenesis and fetal period had no lethal or teratogenic effect although the mean fetal body weight was significantly lower than control.
Authors:
M H El-Dakdoky
Publication Detail:
Type:  Journal Article     Date:  2009-03-28
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1437-41     Citation Subset:  IM    
Affiliation:
Department of Zoology, Girls College for Arts, Science and Education, Ain Shams University, 1 Asmaa Fahmey St., Heliopolis, Cairo 11757, Egypt. mhgawad11@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials / toxicity*
Artemisinins / toxicity*
Embryo Implantation / drug effects
Embryonic Development / drug effects
Female
Fetal Resorption / chemically induced,  pathology
Fetal Weight / drug effects
Lymphocyte Activation / drug effects
Pregnancy
Pregnancy Outcome
Rats
Rats, Wistar
Teratogens*
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Teratogens; 0/artemether

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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