Document Detail

Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins.
MedLine Citation:
PMID:  18804142     Owner:  NLM     Status:  MEDLINE    
Saccharomyces cerevisiae extract (SCE) is used in cosmetics since it can act in oxidative stress and improve skin conditions. This study investigated dermatological effects of cosmetic formulations containing SCE and/or vitamins A, C and E. The formulation studied was supplemented or not (F1: vehicle) with vitamins A, C and E esters (F2) or with SCE (F3) or with the combination of vitamins and SCE (F4). Formulations were patch tested on back skin of volunteers. For efficacy studies, formulations were applied on volunteers and transepidermal water loss (TEWL), skin moisture (SM), skin microrelief (SMR) and free radicals protection were analysed after 3h, 15 and 30 days of application. Volunteers were also asked about efficacy perception. It was observed that F4 provoked a slight erythema in one volunteer. All formulations enhanced forearm SM. Only F3 and F4 presented long term effects on SMR and showed higher texture values; F3 had the highest brightness values. Our results suggest that vitamins and SCE showed effects in SM and SMR. Only formulations containing SC had long term effects in the improvement of SMR. Thus, these kinds of evaluations are very important in cosmetics development to evaluate the best risk and benefit correlation.
L R Gaspar; F B Camargo; M D Gianeti; P M B G Maia Campos
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-09-02
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3493-500     Citation Subset:  IM    
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Av. do Café s/n, Bairro Monte Alegre, Ribeirão Preto, Sao Paulo 14 040-903, Brazil.
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MeSH Terms
Administration, Cutaneous
Ascorbic Acid / administration & dosage,  pharmacology
Body Water / metabolism*
Cosmetics / administration & dosage,  chemistry,  pharmacology*
Dose-Response Relationship, Drug
Drug Combinations
Middle Aged
Saccharomyces cerevisiae / chemistry*
Skin / drug effects*,  metabolism
Time Factors
Vitamin A / administration & dosage,  pharmacology
Vitamin E / administration & dosage,  pharmacology
Vitamins / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Cosmetics; 0/Drug Combinations; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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