| Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins. | |
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MedLine Citation:
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PMID: 18804142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Saccharomyces cerevisiae extract (SCE) is used in cosmetics since it can act in oxidative stress and improve skin conditions. This study investigated dermatological effects of cosmetic formulations containing SCE and/or vitamins A, C and E. The formulation studied was supplemented or not (F1: vehicle) with vitamins A, C and E esters (F2) or with SCE (F3) or with the combination of vitamins and SCE (F4). Formulations were patch tested on back skin of volunteers. For efficacy studies, formulations were applied on volunteers and transepidermal water loss (TEWL), skin moisture (SM), skin microrelief (SMR) and free radicals protection were analysed after 3h, 15 and 30 days of application. Volunteers were also asked about efficacy perception. It was observed that F4 provoked a slight erythema in one volunteer. All formulations enhanced forearm SM. Only F3 and F4 presented long term effects on SMR and showed higher texture values; F3 had the highest brightness values. Our results suggest that vitamins and SCE showed effects in SM and SMR. Only formulations containing SC had long term effects in the improvement of SMR. Thus, these kinds of evaluations are very important in cosmetics development to evaluate the best risk and benefit correlation. |
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Authors:
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L R Gaspar; F B Camargo; M D Gianeti; P M B G Maia Campos |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-09-02 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 46 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-05 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 3493-500 Citation Subset: IM |
Affiliation:
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Av. do Café s/n, Bairro Monte Alegre, Ribeirão Preto, Sao Paulo 14 040-903, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adult Ascorbic Acid / administration & dosage, pharmacology Body Water / metabolism* Cosmetics / administration & dosage, chemistry, pharmacology* Dose-Response Relationship, Drug Drug Combinations Face Female Forearm Humans Middle Aged Saccharomyces cerevisiae / chemistry* Skin / drug effects*, metabolism Time Factors Vitamin A / administration & dosage, pharmacology Vitamin E / administration & dosage, pharmacology Vitamins / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cosmetics; 0/Drug Combinations; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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