| Evaluation of deafness in American Paint Horses by phenotype, brainstem auditory-evoked responses, and endothelin receptor B genotype. | |
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MedLine Citation:
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PMID: 19912043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate deafness in American Paint Horses by phenotype, clinical findings, brainstem auditory-evoked responses (BAERs), and endothelin B receptor (EDNBR) genotype. DESIGN: Case series and case-control studies. ANIMALS: 14 deaf American Paint Horses, 20 suspected-deaf American Paint Horses, and 13 nondeaf American Paint Horses and Pintos. PROCEDURES: Horses were categorized on the basis of coat color pattern and eye color. Testing for the EDNBR gene mutation (associated with overo lethal white foal syndrome) and BAERs was performed. Additional clinical findings were obtained from medical records. RESULTS: All 14 deaf horses had loss of all BAER waveforms consistent with complete deafness. Most horses had the splashed white or splashed white-frame blend coat pattern. Other patterns included frame overo and tovero. All of the deaf horses had extensive head and limb white markings, although the amount of white on the neck and trunk varied widely. All horses had at least 1 partially heterochromic iris, and most had 2 blue eyes. Ninety-one percent (31/34) of deaf and suspected-deaf horses had the EDNBR gene mutation. Deaf and suspected-deaf horses were used successfully for various performance events. All nondeaf horses had unremarkable BAER results. CONCLUSIONS AND CLINICAL RELEVANCE: Veterinarians should be aware of deafness among American Paint Horses, particularly those with a splashed white or frame overo coat color pattern, blend of these patterns, or tovero pattern. Horses with extensive head and limb markings and those with blue eyes appeared to be at particular risk. |
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Authors:
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K Gary Magdesian; D Colette Williams; Monica Aleman; Richard A Lecouteur; John E Madigan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Veterinary Medical Association Volume: 235 ISSN: 0003-1488 ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 1204-11 Citation Subset: IM |
Affiliation:
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Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA. kgmagdesian@vmth.ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal Deafness / diagnosis, genetics, veterinary* Evoked Potentials, Auditory, Brain Stem / physiology* Female Genetic Predisposition to Disease* Genotype Horse Diseases / diagnosis*, genetics Horses Iris Male Pigmentation / genetics, physiology Receptors, Endothelin / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Endothelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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