Document Detail


Evaluation of the cytotoxicity of dihydroxytryptamines and 5-hydroxytryptamine antagonists as cytotoxic agents in dimethylhydrazine-induced adenocarcinomata.
MedLine Citation:
PMID:  35286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytotoxicity of 5,6-dihydroxytryptamine (5,6-DHT), 5,7-dihydroxytryptamine (5,7-DHT), bromolysergic acid diethylamide (BOL), methysergide, and cyproheptadine, and also of 5,6-DHT together with either BOL, methysergide, or cyproheptadine in dimethylhydrazine-induced (DMH) carcinomata of rat colon was evaluated by estimating the percentage of necrotic cells in histological sections of tissues taken 15 h after injection of each of the drugs. In addition, the influence of methysergide and cyproheptadine on the tumour cell mitotic rate was estimated by means of a stathmokinetic technique. Both 5,6-DHT and 5,7-DHT were cytotoxic at each dose tested and for each of these agents the percentage of necrotic cells was directly correlated with the dose of drug used. BOL was not found to be cytotoxic to the colonic carcinomata, whereas both methysergide and cyproheptadine did cause detectable tumour cell necrosis. Methysergide was also found to accelerate tumour cell proliferation, whereas cyproheptadine did not. BOL competitively inhibited the cytotoxicity of 5,6-DHT and neither methysergide nor cyproheptadine potentiated the effect of 5,6 DHT.
Authors:
P J Tutton; D H Barkla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer chemotherapy and pharmacology     Volume:  1     ISSN:  0344-5704     ISO Abbreviation:  Cancer Chemother. Pharmacol.     Publication Date:  1978  
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806519     Medline TA:  Cancer Chemother Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
5,6-Dihydroxytryptamine / pharmacology*
5,7-Dihydroxytryptamine / pharmacology*
Adenocarcinoma / chemically induced,  drug therapy*
Animals
Antineoplastic Agents* / therapeutic use
Cyproheptadine / pharmacology
Dihydroxytryptamines / pharmacology*
Dimethylhydrazines / pharmacology
Lysergic Acid Diethylamide / pharmacology
Male
Methysergide / pharmacology
Mitosis / drug effects
Neoplasms, Experimental / chemically induced,  drug therapy
Rats
Serotonin Antagonists / pharmacology*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Dihydroxytryptamines; 0/Dimethylhydrazines; 0/Serotonin Antagonists; 129-03-3/Cyproheptadine; 31363-74-3/5,7-Dihydroxytryptamine; 361-37-5/Methysergide; 50-37-3/Lysergic Acid Diethylamide; 5090-36-8/5,6-Dihydroxytryptamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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