Document Detail

Evaluation of cyclin D1 expression and its subcellular distribution in mouse tissues.
MedLine Citation:
PMID:  15575889     Owner:  NLM     Status:  MEDLINE    
Cyclin D1 is a key cell-cycle regulatory protein required for the cell to progress through G1 to S phase. We have shown by Western blot analysis that cyclin D1 has a wide distribution in adult mouse tissues, with its level of expression being tissue-dependent. Immunohistochemistry has also shown that cyclin D1 may be present in the cytoplasm, in the nucleus or in both these cell compartments: cytoplasmic staining was observed in both proliferating cells (e.g. kidney, intestine, stomach and salivary gland) and in the non-dividing cells (the mature neurons of adult brain), while nuclear staining was seen in the neurons of the embryonic nervous system. Immunoelectron microscopy results indicate that, in tissues where cyclin D1 is present in both compartments (e.g. intestinal enterocytes), it may move via nuclear pores from the nucleus to the cytoplasm, and vice versa. The findings as a whole suggest that cyclin D1 may play multiple roles within specific tissues, probably by interacting with different substrates, and that its transit between nuclear and cytoplasmic compartments may help maintain cell homeostasis.
Maria De Falco; Valentina Fedele; Luca De Luca; Roberta Penta; Giuliano Cottone; Ivan Cavallotti; Vincenza Laforgia; Antonio De Luca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of anatomy     Volume:  205     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-02-16     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  England    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Department of Evolutive and Comparative Biology, University of Naples Federico II, Naples, Italy.
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MeSH Terms
Biological Transport
Cell Cycle
Cell Nucleus / chemistry*
Cyclin D1 / analysis*
Cytoplasm / chemistry*
Epithelial Cells / chemistry*
Immunoblotting / methods
Immunohistochemistry / methods
Intestines / chemistry
Kidney Tubules / chemistry
Lung / chemistry
Microscopy, Immunoelectron
Neurons / chemistry
Salivary Glands / chemistry
Stomach / chemistry
Reg. No./Substance:
136601-57-5/Cyclin D1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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