Document Detail


Evaluation of cutaneous angioimmunoblastic T-cell lymphoma.
MedLine Citation:
PMID:  21550134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Angioimmunoblastic T-cell lymphoma (AITL) accounts for 18% of peripheral T-cell lymphomas worldwide. Skin involvement occurs in up to 50% of patients but poses a diagnostic dilemma because of the limited number of reported cases and subsequent lack of established diagnostic criteria.
OBJECTIVE: The purpose of this review is to examine common clinical, histologic, and molecular findings in cases of AITL with the hope of improving the diagnostic accuracy of this challenging condition.
METHODS: We present a case of AITL and conducted a review of the literature.
RESULTS: The common clinical and histologic features in cases of AITL are nonspecific. However, newer immunohistochemical stains and gene rearrangement studies appear very promising at improving diagnostic capabilities.
LIMITATIONS: There was a paucity of reported cases of AITL in the literature, and this review is retrospective.
CONCLUSION: AITL presents with nonspecific clinical and histologic findings, but immunohistochemical stains and gene rearrangements can help establish the diagnosis.
Authors:
Brundha Balaraman; Jarod A Conley; David M Sheinbein
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2011-05-06
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  65     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-16     Completed Date:  2011-11-23     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Affiliation:
Washington University, Saint Louis, Missouri, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Arthralgia / diagnosis,  pathology
Cyclophosphamide / administration & dosage
Deoxycytidine / administration & dosage,  analogs & derivatives
Diphtheria Toxin / therapeutic use
Doxorubicin / administration & dosage
Epstein-Barr Virus Infections / diagnosis,  pathology
Gene Rearrangement, T-Lymphocyte
Humans
Immunoblastic Lymphadenopathy / diagnosis,  pathology*,  therapy,  virology
Interleukin-2 / therapeutic use
Lymphoma, T-Cell, Cutaneous / diagnosis,  pathology*,  therapy,  virology
Male
Methotrexate / administration & dosage
Prednisolone / administration & dosage
Pruritus / diagnosis
Recombinant Fusion Proteins / therapeutic use
Retrospective Studies
Skin Neoplasms / diagnosis,  pathology*,  therapy,  virology
Stem Cell Transplantation
Vinblastine / administration & dosage,  analogs & derivatives
Vincristine / administration & dosage
Chemical
Reg. No./Substance:
0/Diphtheria Toxin; 0/Interleukin-2; 0/Recombinant Fusion Proteins; 23214-92-8/Doxorubicin; 25E79B5CTM/denileukin diftitox; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 57-22-7/Vincristine; 59-05-2/Methotrexate; 865-21-4/Vinblastine; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine; Q6C979R91Y/vinorelbine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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