| Evaluation of creatine kinase level during long-term tocolysis. | |
| | |
MedLine Citation:
|
PMID: 12530103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This study was performed to evaluate serum creatine kinase (CK) levels during tocolytic therapy. METHODS: A retrospective study was performed in 27 patients who were treated with intravenous tocolytic agents for more than one week. The first-line tocolytic agent was ritodrine hydrochloride, followed by concomitant magnesium sulfate (MgSO4). The serum CK level was measured on admission and every week thereafter. The patients were divided into the normal CK (group 1) and abnormal CK (> 150 IU/L) (group 2) groups. RESULTS: Seventeen patients received both ritodrine hydrochloride and MgSO4. The CK levels in all patients rose significantly from 58.4 +/- 30.8 IU/L on admission to 116.0 +/- 68.7 IU/L on day 7 (p = 0.002). Abnormal elevation of CK occurred in 7 (25.9%) of the 27 patients. Significant differences were found between groups 1 and 2 in the total doses of ritodrine and MgSO4 (p = 0.046 and p = 0.0028, respectively). All patients in group 2 received ritodrine in combination with MgSO4 (p = 0.018). CONCLUSION: When tocolytic therapy continued for more than 1 week, nearly one-fourth of patients showed an increase in CK level above the normal range. |
| | |
Authors:
|
Yoshio Matsuda; Yumiko Nagayoshi; Nami Kirihara |
Related Documents
:
|
2632253 - Creatine kinase-bb in the cerebrospinal fluid as a marker of cns metastases and leptome... 9494553 - Tps and ca 125 levels in serum, cyst fluid and ascites of patients with epithelial ovar... 1008483 - Red cell uroporphyrinogen i synthetase in acute intermittent porphyria. |
Publication Detail:
|
Type: Comment; Journal Article |
Journal Detail:
|
Title: Journal of perinatal medicine Volume: 30 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2002 |
Date Detail:
|
Created Date: 2003-01-17 Completed Date: 2003-05-01 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 476-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima. ymatsuda@obgy.twmu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Creatine Kinase / blood* Female Humans Infusions, Intravenous Magnesium Sulfate / administration & dosage, adverse effects* Medical Records Obstetric Labor, Premature / prevention & control Pregnancy Pregnancy Complications / blood, chemically induced* Retrospective Studies Rhabdomyolysis / blood, chemically induced* Ritodrine / administration & dosage, adverse effects* Tocolytic Agents / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Tocolytic Agents; 26652-09-5/Ritodrine; 7487-88-9/Magnesium Sulfate; EC 2.7.3.2/Creatine Kinase |
| Comments/Corrections | |
Comment On:
|
J Perinat Med. 2002;30(6):514-6
[PMID:
12530109
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Socioeconomic and environmental risk factors of bacterial vaginosis in early pregnancy.
Next Document: Maternal serum glycodelin in premature rupture of membranes.