Document Detail

Evaluation of creatine kinase level during long-term tocolysis.
MedLine Citation:
PMID:  12530103     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was performed to evaluate serum creatine kinase (CK) levels during tocolytic therapy. METHODS: A retrospective study was performed in 27 patients who were treated with intravenous tocolytic agents for more than one week. The first-line tocolytic agent was ritodrine hydrochloride, followed by concomitant magnesium sulfate (MgSO4). The serum CK level was measured on admission and every week thereafter. The patients were divided into the normal CK (group 1) and abnormal CK (> 150 IU/L) (group 2) groups. RESULTS: Seventeen patients received both ritodrine hydrochloride and MgSO4. The CK levels in all patients rose significantly from 58.4 +/- 30.8 IU/L on admission to 116.0 +/- 68.7 IU/L on day 7 (p = 0.002). Abnormal elevation of CK occurred in 7 (25.9%) of the 27 patients. Significant differences were found between groups 1 and 2 in the total doses of ritodrine and MgSO4 (p = 0.046 and p = 0.0028, respectively). All patients in group 2 received ritodrine in combination with MgSO4 (p = 0.018). CONCLUSION: When tocolytic therapy continued for more than 1 week, nearly one-fourth of patients showed an increase in CK level above the normal range.
Yoshio Matsuda; Yumiko Nagayoshi; Nami Kirihara
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  30     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2002  
Date Detail:
Created Date:  2003-01-17     Completed Date:  2003-05-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  476-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima.
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MeSH Terms
Creatine Kinase / blood*
Infusions, Intravenous
Magnesium Sulfate / administration & dosage,  adverse effects*
Medical Records
Obstetric Labor, Premature / prevention & control
Pregnancy Complications / blood,  chemically induced*
Retrospective Studies
Rhabdomyolysis / blood,  chemically induced*
Ritodrine / administration & dosage,  adverse effects*
Tocolytic Agents / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Tocolytic Agents; 26652-09-5/Ritodrine; 7487-88-9/Magnesium Sulfate; EC Kinase
Comment On:
J Perinat Med. 2002;30(6):514-6   [PMID:  12530109 ]

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