| Evaluation of coronary flow reserve using myocardial contrast echocardiography in humans. | |
| | |
MedLine Citation:
|
PMID: 1597227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To evaluate the applicability of myocardial contrast echocardiography for the assessment of coronary blood flow reserve, 21 consecutive patients undergoing coronary angiography were studied. Only patients with a single left anterior descending lesion or normal coronary angiogram were included. Intracoronary injections of sonicated albumin were performed before and after the administration of intracoronary papaverine. Good quality studies at baseline and after the administration of papaverine were obtained in 14 of 21 patients. Ten patients had a significant (greater than 75%) single left anterior descending lesion and four had normal or insignificant lesions (70% or less stenosis) in the left anterior descending coronary artery. Time-intensity curves for the left anterior descending coronary artery region of interest were generated and then the peak contrast intensity (PCI), washout half-time (T1/2) and the area under the curve (AUC) were calculated. The post-papaverine increases in PCI and in the AUC, compared to baseline, were 55 +/- 22% and 102 +/- 14% in the four patients with 70% or less left anterior descending diameter stenosis serving as a control group and 3 +/- 25% and 40 +/- 10%, respectively, in the 10 patients with significant left anterior descending coronary artery disease (mean +/- 1 SD, P less than 0.01). In patients with normal coronary arteriography T1/2 increased after intracoronary injection of papaverine. In patients with severe lesions, either an increase or a decrease in T1/2 was observed. Significant left anterior descending coronary artery stenosis associated with impaired coronary blood flow reserve can be detected by failure of myocardial contrast echocardiographic parameters to increase after injection of papaverine. Mild and transient side effects were noted in three patients. |
| | |
Authors:
|
S A Reisner; L S Ong; P G Fitzpatrick; G S Lichtenberg; J T Sullebarger; M N Allen; R S Meltzer |
Related Documents
:
|
6036537 - Regional myocardial blood flow. 3957477 - The response of the coronary collateral circulation to acute administration of nifedipi... 6885187 - Protective role of collaterals in patients with coronary artery occlusion. 17584717 - Pseudonormalization: clinical, electrocardiographic, echocardiographic, and angiographi... 6601937 - Aortic valve replacement and coronary bypass in patients with severe stenosis of the le... 12718477 - A higher prevalence of abnormal regional cerebral blood flow in patients with syndrome ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: European heart journal Volume: 13 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1992 Mar |
Date Detail:
|
Created Date: 1992-07-07 Completed Date: 1992-07-07 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 389-94 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Rochester, NY. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Albumins / diagnostic use Contrast Media Coronary Angiography Coronary Circulation* / drug effects Coronary Disease / physiopathology, radiography, ultrasonography* Echocardiography* / methods Evaluation Studies as Topic Female Humans Male Middle Aged Papaverine / adverse effects, diagnostic use, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Albumins; 0/Contrast Media; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial contrast echocardiography: influence of ischaemia and hyperaemia in an animal model.
Next Document: Effect of cicletanine on reperfusion-induced arrhythmias and myocardial ion contents: a comparison w...