Document Detail

Evaluation of coronary calcium score by multidetector computed tomography in relation to endothelial function and inflammatory markers in asymptomatic individuals.
MedLine Citation:
PMID:  18441459     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coronary calcification has been correlated with the presence and extent of coronary artery disease (CAD), so in the present study the associations between coronary artery calcification score (CACS) and endothelial dysfunction, as well as the important inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and oxidized low-density lipoprotein (OxLDL), were studied in asymptomatic individuals at intermediate risk for CAD. METHODS AND RESULTS: The study group comprised 177 subjects (103 males) aged 50.6+/-5.9 years. CACS was measured by multidetector computed tomography using the Agatston method. Endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent nitroglycerin-mediated dilatation (NMD) were measured by high-resolution external brachial ultrasound. Coronary artery calcification (CAC) was detected in 82 subjects (52 males), and the median CACS was 143 [31-311.25] units. After adjusting for gender and body mass index, log (CACS +1) correlated positively with age (r=0.401, p<0.001) and IL-6 levels (r=0.442, p<0.001), and negatively with FMD (r=-0.511, p<0.001). The correlations of log (CACS +1) with CRP and OxLDL levels, and with NMD, were non-significant. In a multivariate-adjusted logistic regression model, age (odds ratio (OR) =1.083 [1.014-1.156]), serum IL-6 level (OR=3.837 [2.166-6.798]) and FMD (OR=0.851 [0.793-0.913]) were significantly and independently associated with CAC. CONCLUSIONS: Peripheral endothelial function inversely correlated with CACS, whereas IL-6 level was associated with CACS. Testing for endothelial function and IL-6 level may improve cardiovascular risk assessment and help target the therapeutic strategies in asymptomatic patients at intermediate CAD risk.
Mahmoud M Ramadan; Essam M Mahfouz; Gamal F Gomaa; Tarek A El-Diasty; Louie Alldawi; Taruna Ikrar; Ding Limin; Makoto Kodama; Yoshifusa Aizawa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  778-85     Citation Subset:  IM    
Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / metabolism
Calcinosis / epidemiology*,  immunology,  radiography*
Coronary Artery Disease / epidemiology*,  immunology,  radiography*
Endothelium, Vascular / immunology,  pathology
Interleukin-6 / blood
Lipoproteins, LDL / blood
Logistic Models
Middle Aged
Multivariate Analysis
Risk Assessment
Risk Factors
Tomography, X-Ray Computed / methods*
Vasculitis / epidemiology,  immunology,  radiography
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 9007-41-4/C-Reactive Protein

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