Document Detail

Evaluation of a combined oestrogen-progestogen injectable contraceptive.
MedLine Citation:
PMID:  694639     Owner:  NLM     Status:  MEDLINE    
A combined injection of 50 mg medroxyprogesterone acetate and 10 mg oestradiol cypionate (Cyclo-Provera; Upjohn) was administered monthly for periods ranging from 1 to 18 months, to 120 Black women of reproductive age. No major side-effects were noted, no pregnancies occurred in the 575 cycles studies, and the pattern of regular menstrual bleeding was acceptable. Amenorrhoea occurred in 15,8% of patients but only 2,5% requested a change of treatment. The incidence of amenorrhoea diminished with continued use. This contraceptive regimen appears to be a useful addition to the methods presently available. Certain aspects merit further study.
B Bloch; A H Davies
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  53     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  846-7     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Drug Combinations
Drug Evaluation
Estradiol / administration & dosage,  adverse effects,  analogs & derivatives*
Estradiol Congeners / adverse effects
Injections, Intramuscular
Medroxyprogesterone / administration & dosage*,  adverse effects
Menstruation Disturbances / chemically induced
Reg. No./Substance:
0/Drug Combinations; 0/Estradiol Congeners; 4TI98Z838E/Estradiol; HSU1C9YRES/Medroxyprogesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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