Document Detail

Evaluation of coated oxygenators in cardiopulmonary-bypass systems and their impact on neurocognitive function.
MedLine Citation:
PMID:  16231620     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Coronary artery bypass graft surgery (CABG) using cardiopulmonary bypass (CPB) is assumed to be associated with a decline of neurocognitive functions. This study was designed to analyse the neurocognitive function of patients with coronary heart disease before and after CABG and to determine possible protective effects of oxygenator surface coating on neurological outcome. METHODS: Forty patients scheduled for selective CABG were prospectively randomized into two groups of 20 patients each according to the type of hollow-fibre membrane oxygenator used. Non-coated oxygenators (Group A) were compared to phosphorylcholine (PC)coated oxygenators (Group B). A battery of six neurological tests was administered preoperatively, 7-10 days and 4-6 months after surgery. RESULTS: One patient of Group A suffered from a perioperative stroke and died on postoperative day 3, presumably because of sudden heart failure. Two patients of Group A (10%) developed a symptomatic transitory delirious psychotic syndrome (STPT) on postoperative days 3 and 5. None of the patients of Group B had perioperative complications. The test analysis revealed a trend of declined neurocognitive function early after CABG, but did not show any difference in neurocognitive outcome between the two groups. DISCUSSION: PC coating of the oxygenators did not show any significant benefit on neurocognitive function after CABG using CPB.
Amir Khosravi; Christian A Skrabal; Bernd Westphal; Guenther Kundt; Brigitte Greim; Erwin Kunesch; Andreas Liebold; Gustav Steinhoff
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Perfusion     Volume:  20     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-19     Completed Date:  2005-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-54     Citation Subset:  IM    
Department of Cardiac Surgery, University of Rostock, Rostock, Germany.
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MeSH Terms
Cardiopulmonary Bypass / adverse effects,  instrumentation*
Coated Materials, Biocompatible / standards*,  therapeutic use
Delirium, Dementia, Amnestic, Cognitive Disorders / etiology,  prevention & control
Intraoperative Complications / prevention & control
Mental Processes*
Middle Aged
Neuropsychological Tests
Oxygenators, Membrane / adverse effects*,  standards
Phosphorylcholine / therapeutic use
Protective Agents / standards,  therapeutic use
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Protective Agents; 107-73-3/Phosphorylcholine

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