| Evaluation of coated oxygenators in cardiopulmonary-bypass systems and their impact on neurocognitive function. | |
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MedLine Citation:
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PMID: 16231620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Coronary artery bypass graft surgery (CABG) using cardiopulmonary bypass (CPB) is assumed to be associated with a decline of neurocognitive functions. This study was designed to analyse the neurocognitive function of patients with coronary heart disease before and after CABG and to determine possible protective effects of oxygenator surface coating on neurological outcome. METHODS: Forty patients scheduled for selective CABG were prospectively randomized into two groups of 20 patients each according to the type of hollow-fibre membrane oxygenator used. Non-coated oxygenators (Group A) were compared to phosphorylcholine (PC)coated oxygenators (Group B). A battery of six neurological tests was administered preoperatively, 7-10 days and 4-6 months after surgery. RESULTS: One patient of Group A suffered from a perioperative stroke and died on postoperative day 3, presumably because of sudden heart failure. Two patients of Group A (10%) developed a symptomatic transitory delirious psychotic syndrome (STPT) on postoperative days 3 and 5. None of the patients of Group B had perioperative complications. The test analysis revealed a trend of declined neurocognitive function early after CABG, but did not show any difference in neurocognitive outcome between the two groups. DISCUSSION: PC coating of the oxygenators did not show any significant benefit on neurocognitive function after CABG using CPB. |
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Authors:
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Amir Khosravi; Christian A Skrabal; Bernd Westphal; Guenther Kundt; Brigitte Greim; Erwin Kunesch; Andreas Liebold; Gustav Steinhoff |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Perfusion Volume: 20 ISSN: 0267-6591 ISO Abbreviation: Perfusion Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-19 Completed Date: 2005-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, University of Rostock, Rostock, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiopulmonary Bypass / adverse effects, instrumentation* Coated Materials, Biocompatible / standards*, therapeutic use Delirium, Dementia, Amnestic, Cognitive Disorders / etiology, prevention & control Female Humans Intraoperative Complications / prevention & control Male Mental Processes* Middle Aged Neuropsychological Tests Oxygenators, Membrane / adverse effects*, standards Phosphorylcholine / therapeutic use Protective Agents / standards, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Protective Agents; 107-73-3/Phosphorylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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