Document Detail

Evaluation of changes in myocardial perfusion and function on exercise in patients with coronary artery disease by gated MIBI scintigraphy.
MedLine Citation:
PMID:  8037994     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the ability of gated methoxy-isobutylisonitrile (MIBI) scintigraphy to measure changes in myocardial function as well as perfusion with exercise. SETTING: Regional cardiothoracic centre. PATIENTS: 43 presenting with chest pain, 28 with coronary artery disease on angiography, and 15 with normal coronary arteriograms. RESULTS: Gated perfusion images showed an improvement in detecting regions with stenosed arteries compared with non-gated images (38/55 v 31/55, p < or = 0.01)). Functional analysis showed an increase in fractional shortening of 4.11% in subjects with normal coronary arteries, whereas in those with coronary disease a fall of 0.57% was found (p < or = 0.01). Both perfusion and function imaging showed an improved sensitivity compared with standard exercise testing (p < or = 0.01). When both function and perfusion imaging were analysed all patients with coronary disease were detected. There was agreement in abnormal regions in 33/55 territories supplied by a stenosed artery. Combined perfusion and function detected 49/55 (89%) of abnormal regions, thus improving the overall sensitivity from 38/55 (69%) by perfusion imaging alone (p < or = 0.01). CONCLUSIONS: Gated methoxy-isobutylisonitrile scintigraphy can successfully evaluate perfusion and function on exercise, so improving the diagnostic usefulness of this agent.
P Avery; N Hudson; P Hubner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  70     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1994-08-25     Completed Date:  1994-08-25     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  AIM; IM    
Regional Cardiac Unit, Groby Road Hospital, Leicester.
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MeSH Terms
Coronary Angiography
Coronary Disease / physiopathology*,  radionuclide imaging*
Exercise / physiology*
Exercise Test
Gated Blood-Pool Imaging*
Heart / radionuclide imaging*
Middle Aged
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use
Ventricular Function, Left / physiology*
Reg. No./Substance:
109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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