| Evaluation of changes in myocardial function on exercise in patients with coronary artery disease using gated MIBI scintigraphy. | |
| | |
MedLine Citation:
|
PMID: 1618208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Technetium-99m-methoxy-isobutyl-isonitrile (MIBI) is a myocardial perfusion agent which allows simultaneous assessment of left ventricular function. We evaluated left ventricular (LV) function with exercise using a new method of myocardial profiling in 43 patients with chest pain. Twenty-eight had significant coronary artery disease and 15 were normal on coronary angiography. Results were compared to equilibrium radionuclide ventriculography. MIBI fractional shortening (FS) correlated well with ejection fraction (EF) on exercise (r = 0.79, P = less than 0.001). There was also a good correlation between changes in global function from rest to exercise (r = 0.82, P = less than 0.001) with a sensitivity of diagnosing CAD of 71% and specificity of 80%. New regional wall abnormalities were detected in 25/28 with CAD with a sensitivity of 89% and specificity of 60%. There was also a close correlation between mean diameters measured with gated MIBI scans and volumes measured with RNV, end-diastolic diameter (EDD) versus end-diastolic volume (EDV) r = 0.78 (P = less than 0.001) at rest and r = 0.74 (P = less than 0.001) on exercise and end-systolic diameter (ESD) versus end-systolic volume (ESV) r = 0.72 (P = less than 0.001) at rest and r = 0.72 (P = less than 0.001) on exercise. This produced a sensitivity for detecting CAD of 79% and a specificity of 73%. These results show that gated MIBI scanning on exercise provides information comparable to RNV so enhancing the diagnostic usefulness of MIBI. |
| | |
Authors:
|
P G Avery; H Williams; M Y Early; N M Hudson; P J Hubner |
Related Documents
:
|
19324258 - Post-exercise assessment of cardiac repolarization alternans in patients with coronary ... 8497108 - Effects of exercise and pacing loads on myocardial amino acid balance in patients with ... 11572658 - Adgvvegf121.10 (genvec). 857728 - The detection of asympatomatic coronary artery disease. 7293668 - Iodine metabolism and the effect of tsh in thyroid glands of early bovine embryos. 20095218 - Effect of ventriculectomy versus ventriculocordectomy on upper airway noise in draught ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European heart journal Volume: 13 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1992 May |
Date Detail:
|
Created Date: 1992-08-03 Completed Date: 1992-08-03 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 646-54 Citation Subset: IM |
Affiliation:
|
Regional Cardiothoracic Unit, Groby Road Hospital, Leicester. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Contrast Media* Coronary Disease / physiopathology*, radionuclide imaging Exercise / physiology* Exercise Test* Female Gated Blood-Pool Imaging / methods Humans Male Middle Aged Nitriles / diagnostic use Organotechnetium Compounds / diagnostic use Technetium Tc 99m Sestamibi Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Nitriles; 0/Organotechnetium Compounds; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Doppler echocardiographic observations of diastolic trans-septal flow through small ventricular sept...
Next Document: A prospective study on percutaneous coronary angioscopy with different guiding techniques in patient...