Document Detail

Evaluation of changes in myocardial function on exercise in patients with coronary artery disease using gated MIBI scintigraphy.
MedLine Citation:
PMID:  1618208     Owner:  NLM     Status:  MEDLINE    
Technetium-99m-methoxy-isobutyl-isonitrile (MIBI) is a myocardial perfusion agent which allows simultaneous assessment of left ventricular function. We evaluated left ventricular (LV) function with exercise using a new method of myocardial profiling in 43 patients with chest pain. Twenty-eight had significant coronary artery disease and 15 were normal on coronary angiography. Results were compared to equilibrium radionuclide ventriculography. MIBI fractional shortening (FS) correlated well with ejection fraction (EF) on exercise (r = 0.79, P = less than 0.001). There was also a good correlation between changes in global function from rest to exercise (r = 0.82, P = less than 0.001) with a sensitivity of diagnosing CAD of 71% and specificity of 80%. New regional wall abnormalities were detected in 25/28 with CAD with a sensitivity of 89% and specificity of 60%. There was also a close correlation between mean diameters measured with gated MIBI scans and volumes measured with RNV, end-diastolic diameter (EDD) versus end-diastolic volume (EDV) r = 0.78 (P = less than 0.001) at rest and r = 0.74 (P = less than 0.001) on exercise and end-systolic diameter (ESD) versus end-systolic volume (ESV) r = 0.72 (P = less than 0.001) at rest and r = 0.72 (P = less than 0.001) on exercise. This produced a sensitivity for detecting CAD of 79% and a specificity of 73%. These results show that gated MIBI scanning on exercise provides information comparable to RNV so enhancing the diagnostic usefulness of MIBI.
P G Avery; H Williams; M Y Early; N M Hudson; P J Hubner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  646-54     Citation Subset:  IM    
Regional Cardiothoracic Unit, Groby Road Hospital, Leicester.
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MeSH Terms
Contrast Media*
Coronary Disease / physiopathology*,  radionuclide imaging
Exercise / physiology*
Exercise Test*
Gated Blood-Pool Imaging / methods
Middle Aged
Nitriles / diagnostic use
Organotechnetium Compounds / diagnostic use
Technetium Tc 99m Sestamibi
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Contrast Media; 0/Nitriles; 0/Organotechnetium Compounds; 109581-73-9/Technetium Tc 99m Sestamibi

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