Document Detail


Evaluation of cervical stiffness during pregnancy using semiquantitative ultrasound elastography.
MedLine Citation:
PMID:  23151941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate cervical stiffness during pregnancy using ultrasound-derived elastography, a method used to estimate the average tissue displacement (strain) within a defined region of interest when oscillatory compression is applied.
METHODS: Strain was calculated in two regions of interest, the endocervical canal and the entire cervix, from three anatomical planes of the cervix: mid-sagittal in the plane used for cervical length measurement and in cross-sectional planes located at the internal and external cervical os. Associations between strain values, method of ascertainment and patient characteristics were assessed using linear mixed models to account for within-subject correlation. Inter-rater agreement in defining the degree of cervical stiffness was evaluated in 120 regions of interest acquired by two operators in 20 patients.
RESULTS: A total of 1557 strain estimations were performed in 262 patients at 8-40 weeks of gestation. Adjusting for other sources of variation, (1) cervical tissue strain estimates obtained in the endocervical canal were on average 33% greater than those obtained in the entire cervix; (2) measurements obtained in the cross-sectional plane of the external cervical os and sagittal plane were 45% and 13% greater than those measured in the cross-sectional plane of the internal cervical os, respectively; (3) mean strain rates were 14% and 5% greater among parous women with and without a history of preterm delivery compared with those of nulliparous women, respectively, and were on average 13% greater among women with a cervical length of between 25 and 30 mm compared to those with a cervical length of > 30 mm; and (4) cervical tissue strain was more strongly associated with cervical length than with gestational age.
CONCLUSION: Semiquantitative elastography can be employed to evaluate changes in cervical stiffness during pregnancy.
Authors:
E Hernandez-Andrade; S S Hassan; H Ahn; S J Korzeniewski; L Yeo; T Chaiworapongsa; R Romero
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Intramural     Date:  2013-01-08
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  41     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-07-11     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cervical Length Measurement / methods
Cervix Uteri / physiology*,  ultrasonography
Elasticity / physiology
Elasticity Imaging Techniques / methods
Female
Humans
Observer Variation
Parity
Pregnancy / physiology*
Pregnancy Trimesters
Stress, Physiological / physiology
Ultrasonography, Prenatal / methods
Young Adult
Grant Support
ID/Acronym/Agency:
ZIA HD002400-22/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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