Document Detail

Evaluation of cell proliferation rate in non-dysplastic leukoplakias.
MedLine Citation:
PMID:  19767704     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).
STUDY DESIGN: The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosis with acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded.
RESULTS: The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasal layer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oral epithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cell proliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presented a higher proliferative behavior when compared to normal oral epithelium.
CONCLUSION: It may be suggested that non-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showed a proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increase knowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis.
Laura-de Campos Hildebrand; Vinicius-Coelho Carrard; Isabel-da Silva Lauxen; Onofre-Francisco de Quadros; Anna-Cecília-Moraes Chaves; Manoel Sant' Ana-Filho
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Publication Detail:
Type:  Journal Article     Date:  2010-03-01
Journal Detail:
Title:  Medicina oral, patología oral y cirugía bucal     Volume:  15     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-06-30     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  e328-34     Citation Subset:  D; IM    
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MeSH Terms
Antigens, Nuclear
Cell Proliferation*
Leukoplakia, Oral / pathology*
Middle Aged
Reg. No./Substance:
0/Antigens, Nuclear; 0/nucleolar organizer region associated proteins

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