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Evaluation of the catheter positioning for neurally adjusted ventilatory assist.
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PMID:  19652950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: During neurally adjusted ventilatory assist (NAVA) the ventilator is driven by the patients electrical activation of the diaphragm (EAdi), detected by a special esophageal catheter. A reliable positioning of the EAdi-catheter is mandatory to trace a representative EAdi signal. We aimed to determine whether a formula that is based on the measurement from nose to ear lobe to xiphoid process of the sternum (NEX distance) modified for EAdi-catheter placement (NEX(mod)) is sufficient for predicting the accurate catheter position.
METHODS: Twenty-six patients were enrolled in this study. The optimal EAdi-catheter position (OPT) was defined by: (1) stable EAdi signal, (2) electrical activity highlighted in central leads of the catheter positioning tool, and (3) absence of p-wave in distal lead. Afterwards NEX(mod) was calculated and compared to the OPT finding.
RESULTS: At NEX(mod) the EAdi signal was suitable for running NAVA in 18 out of 25 patients (72%). NEX(mod) was identical with OPT in four patients (16%). NAVA was possible in all patients at OPT. Median OPT position was 2 cm caudal of the NEX(mod) ranging from 3 cm too cranial to a position 12 cm too caudal (P < 0.01). In one patient excluded from further analysis EAdi-catheter placement led to the diagnosis of bilateral injury of the phrenic nerves.
CONCLUSIONS: EAdi-catheter placement based on the NEX(mod) formula allows running NAVA in about two-thirds of all patients. The additional tools provided are efficient and facilitate the correct positioning of the EAdi-catheter for neurally adjusted ventilatory assist.
Authors:
Jürgen Barwing; Markus Ambold; Nadine Linden; Michael Quintel; Onnen Moerer
Publication Detail:
Type:  Journal Article     Date:  2009-08-04
Journal Detail:
Title:  Intensive care medicine     Volume:  35     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2010-02-02     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1809-14     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, Emergency and Intensive Care Medicine, Georg-August University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Catheterization / methods*
Female
Humans
Male
Middle Aged
Respiration, Artificial / methods*
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Journal ID (nlm-ta): Intensive Care Med
ISSN: 0342-4642
ISSN: 1432-1238
Publisher: Springer-Verlag, Berlin/Heidelberg
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© The Author(s) 2009
Received Day: 26 Month: 4 Year: 2009
Accepted Day: 9 Month: 7 Year: 2009
Electronic publication date: Day: 4 Month: 8 Year: 2009
Print publication date: Month: 10 Year: 2009
Volume: 35 Issue: 10
First Page: 1809 Last Page: 1814
ID: 2749172
PubMed Id: 19652950
Publisher Id: 1587
DOI: 10.1007/s00134-009-1587-0
issue-copyright-statement: © Copyright jointly hold by Springer and ESICM 2009

Evaluation of the catheter positioning for neurally adjusted ventilatory assist
Jürgen BarwingAff1
Markus AmboldAff1
Nadine LindenAff1
Michael QuintelAff1
Onnen MoererAff1 Address: +49-551-399561 omoerer@gwdg.de
Department of Anaesthesiology, Emergency and Intensive Care Medicine, Georg-August University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Introduction

Neurally adjusted ventilatory assist (NAVA) is a new mode of assisted mechanical ventilation [15]. During NAVA the ventilator is triggered by the electrical activity of the diaphragm (EAdi), assessed by a special gastric tube (EAdi-catheter). Patient–ventilator synchronization is increased by neural control [6]. Pressure support is applied in proportion to the amplitude of the EAdi, which represents direct control by the patients own respiratory center [15, 7].

During NAVA reliable positioning of the EAdi-catheter is mandatory in order to trace a representative EAdi signal from the diaphragm. One method to predict the correct position of a gastric feeding tube is based on the measure from the nose to the ear lobe to the xiphoid process of the sternum (NEX distance) [8]. Using the NEX distance the gastric feeding tube was placed trans nasally more than 10 cm into the stomach in 26% of 99 adult cadavers and five normal adult volunteers. For EAdi-catheter positioning the manufacturer suggests a modified NEX distance which aims to predict the ideal position of the electrode array. There are no studies that evaluated this approach. Therefore we aimed to determine whether or not it is sufficient to place the catheter purely by using the modified NEX distance.


Methods

This observational study was performed after ethics committee approval at the anaesthesiological ICU, University of Goettingen, Germany. NAVA was initiated with the intention to improve patient respirator synchrony and to facilitate respirator weaning.

Patients were treated with a ventilator capable of NAVA (Servo-i, Maquet Critical Care, Solna, Sweden). Pressure support ventilation was used prior to EAdi-catheter positioning.

Patients were in supine position with the upper part of the body elevated in a 30° angle and gastric content was drained via the nasogastric tube. Afterwards the standard tubing was replaced by the EAdi-catheter (16 french diameter, 125 cm long; Maquet Critical Care, Solna, Sweden), inserted nasally to a maximum distance of 80 cm.

For EAdi measurement this tube is mounted with an electrode array of nine electrode rings on the distal part of the catheter at intervals of 16 mm, starting 120 mm from the tip.

Catheter positioning was monitored by a special tool implemented in the ventilator. It displays an EAdi curve and four raw leads not filtered for ECG activity. The electrical activity used for generating the EAdi signal is highlighted. The position of the electrodes in relation to the heart and diaphragm can be estimated by evaluating the different leads for presence/absence of p-wave and QRS complex. During the placement procedure the catheter was pulled out in steps of 1 cm. EAdi signal and electrical activity from raw leads were recorded at each step using special software (NAVA tracker, Maquet Critical Care, Solna, Sweden) for offline analysis until ECG-signals disappeared. The “optimal” catheter position (OPT) was identified by checking the recording for the following three criteria: (1) stable EAdi signal, (2) electrical activity highlighted in central leads of the catheter positioning tool, and (3) absence of p-wave in distal lead. Within the catheter positions that fulfilled the above mentioned criteria we chose the one with the maximum EAdi value as OPT.

Afterwards we calculated the insertion distance of the EAdi-catheter (NEXmod) by the formula proposed by the manufacturer (Maquet catheter packaging).

[Formula ID: Equa]
[\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {\text{NEX}}_{\bmod } = \;\left( {{\text{NEX}}\; \times \;0. 9} \right) + 1 8\left( {{\text{for}}\;{\text{the}}\; 1 6\;{\text{F}} .\;{\text{EAdi}}\hbox{-}{\text{catheter}}} \right) $$\end{document}]
In the formula the measured NEX distance is multiplied by a correction factor (NEX × 0.9 for nasal catheter insertion) in order to predict the distance to the crural diaphragm. Depending on the catheter size used, a constant is added to compensate for the varying electrode array localisation (“+18” cm for the 16 F, 125 cm catheter).

For NEX measurement the patient was placed supine and the outer canthus of the patient’s eye was vertically aligned with the tragus of the ear to decrease errors resulting from head tilt.

Data on NEXmod and OPT position were compared by Wilcoxon matched pairs.


Results

Patient characteristics of 26 enrolled patients are presented in Table 1.

EAdi-catheter placement was possible in all patients and enteral nutrition via the EAdi-catheter was continued uneventfully during NAVA.

p-Waves were absent in seven patients (six due to atrial fibrillation). In one patient (25 + 1), treated with an extracorporal cardiac assist device, there was no detectable EAdi signal although the patient was able to trigger pressure support ventilation (PSV) by his auxiliary respiratory muscles. Since cervical magnetic stimulation of the phrenic nerves did not result in any diaphragmatic response, bilateral injury was suspected and the patient excluded from further data analysis.

In patient 19 the EAdi-catheter was positioned endotracheally first. The suspected malposition was detected at once by complete lack of stable EAdi and ECG-signals and corrected immediately after verification by chest X-ray.

In patient 24 (8 years post gastrectomy) the catheter positioning tool did not highlight the electrical activity of the diaphragm comprehensibly although it was present.

At NEXmod the EAdi signal was suitable for running NAVA in 18 patients (72%). The remaining seven patients (28%) had an inadequate signal quality, thus NAVA was impossible (Fig. 1). Six of these patients showed the alarm “check catheter position”. NAVA was possible at OPT position in all patients. The NEXmod position was identical with the OPT position in four patients (16%). In general we found the OPT position caudal of the NEXmod (Fig. 2). The median difference was 2 cm and the difference ranged from 3 cm too cranial to a position 12 cm too caudal (P < 0.01). Patient 7 (12 cm difference) had a short neck and low lying ears which led to the suspected diagnosis of a Laurence–Moon–Biedl–Bardet–Syndrom [9, 10] and should be regarded as an outlier. At NEXmod position the catheter positioning tool highlighted the central leads in ten cases (42%). p-Wave was absent in the distal lead in nine cases (47% of patients with p-waves) (Fig. 1). The criterion “highlighted electrical activity in central leads” narrowed the OPT position down to an area of 2–7 cm. In consideration of “absence of p-wave”, the OPT position could additionally be narrowed down to an area of 2–5 cm.


Discussion

During NAVA, correct placement of the EAdi-catheter is mandatory to deduce a reliable EAdi signal for respirator control. The modified NEX distance successfully predicted the EAdi-catheter insertion distance in 18 of 25 patients and was identical with the OPT position in four patients. In combination with the catheter positioning tool, catheter placement was possible in all 25 patients.

Former clinical investigations regarding EAdi-catheter positioning refer to the work of Beck [11], where the optimal catheter position was defined by an electromyographic signal from the central electrodes highest in center frequency and reduced in root mean square. Brander [3] additionally judged the correct position by ECG interpretation.

In this study, different information provided by the catheter positioning tool were considered. The anatomical proximity of the right atrium and diaphragm allows an ECG guided positioning of the EAdi-catheter. The progressively decreasing amplitude of the p-wave from the cranial to the caudal electrodes and its absence in the distal lead indicates a position caudal of the right atrium [3]. The catheter positioning tool highlights the leads used for generating the EAdi signal. A catheter position at which the signal for respirator control is taken from the center of the electrode array is advantageous, because displacement of the diaphragm during in- and expiration will most likely not exceed beyond the electrode array. The alarm “check catheter position” appears in this case and proved to be a reliable indicator of a bad catheter position.

We found a median difference of 2 cm with the OPT situated distal of the NEXmod position. Although NEXmod and OPT positions were identical in only four patients, running the NAVA mode was possible in 18 patients at NEXmod position. The diaphragm forms a muscular “tunnel” of 2–3 cm covering the oesophagus [12]. This explains why we found stable signals over a certain range and could use NAVA at most NEXmod positions. However, in seven patients with a NEXmod to OPT difference greater than 3 cm, running NAVA was impossible at NEXmod position due to impaired EAdi signal detection. Thus the positioning tool did not only ensure the correct catheter position but also allowed running NAVA in those patients were NEXmod failed to predict a good position.

The position of the diaphragm depends on the application of PEEP, body position and intra-abdominal pressure (IAP), respectively [1315]. The patients included in our study were placed supine with the upper part of the body elevated in a 30° angle for catheter positioning and had a median PEEP level of 8 cmH2O. Pressure support ventilation with zero PEEP compared to a PEEP level of 10 cm H2O results in a 2 cm shift caudal regarding the middle part of the diaphragm [14]. Although we didn’t measure intra-abdominal pressure there was no clinical suspicion of such. The body position and application of PEEP may have contributed to the fact, that OPT position was found distal of the NEXmod position.

In one patient missing EAdi led to the diagnosis of bilateral phrenic nerve injury. The patient with suspected Laurence–Moon–Biedl–Bardet–Syndrom represented an obvious problem with NEXmod calculation that was predictable due to the askew anatomy. In one patient (post gastric surgery) the catheter positioning tool did not provide reliable data, nevertheless we were able to treat the patient with NAVA. Thus gastric surgery might be considered as a relative contraindication for EAdi-catheter placement.


Conclusion

Positioning the EAdi-catheter using NEXmod gives a good approximation of the catheter position in most patients. The additional tools for catheter positioning are needed to ensure an optimal position, especially in those patients were NEXmod fails. Further studies based on a larger set of patients are required to enhance the accuracy of the NEX formula taking into account PEEP, body position and IAP, respectively.


Open Access

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.


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Figures

[Figure ID: Fig1]
Fig. 1 

Comparison of the different procedures of EAdi-catheter positioning in 25 patients. The different variables considered for optimal catheter placement (OPT) (EAdi signal, highlighted EAdi in central leads and no p-wave in lead one) and the ventilators information on bad catheter positioning (Alarm: “check catheter position”) are compared to the NEXmod method, which is based on anatomical distance measure between xiphoid, earlobe and nose tip. Note: at NEXmod NAVA was possible (squares) in 72% of patients whereas in seven patients (filled circles) NAVA was not possible at NEXmod. The highlighted EAdi leads and p-wave interpretation indicated an EAdi-catheter position that was too cranial in five patients. In six out of seven patients the “check catheter position” alarm was active. From left to right: EAdi signal: percentage of maximum EAdi signal at different EAdi-catheter insertion distances. Data were normalized for OPT position and displayed as mean of 25 patients. Highlighted EAdi in central leads: percentage of patients with highlighted EAdi in leads two and three of the catheter positioning tool, normalized for OPT position and displayed as mean of 25 patients. Alarm “check catheter position”: percentage of patients with alarm “check catheter position” at different catheter positions. No p-wave in distal lead: percentage of patients with no detectable p-wave in distal lead of the catheter positioning tool normalized for OPT position, displayed as mean of 18 patients; patients NEXmod position: NEXmod position of 25 patients in relation to their OPT catheter position. Open squares NAVA was possible in these patients at NEXmod position; filled circle NAVA was not possible in these patients at NEXmod position



[Figure ID: Fig2]
Fig. 2 

Bland–Altman plot. Plot of difference of OPT and NEXmod against mean of OPT and NEXmod. Solid line shows mean of difference, dotted line shows mean ± 2 SD. [16] The figure shows a mean difference of 2.2 cm between OPT and NEXmod and one outlier



Tables
[TableWrap ID: Tab1] Table 1 

Basic patient characteristics including gender, age, height, body mass index (BMI), Reason for ICU admission (Reason adm.), severity off illness on admission evaluated by SAPS II, positive endexpiratory pressure (PEEP) during EAdi-catheter placement and heart rhythm


Patient Gender Age (years) Height (cm) BMI Reason adm. SAPS II PEEP (cmH2O) Heart rhythm NEXmod (cm) OPT (cm) Diff. (cm)
1 M 56 182 37.7 CHD 29 8 SR 70.2 67 −3.2
2 M 41 190 23.5 TBI 51 8 SR 66.6 71 4.4
3 F 76 165 29.4 CPR 65 8 SR 56.7 65 8.3
4 F 79 150 29.3 AS 52 11 SR 60.3 60 −0.3
5 M 33 190 27.7 TBI 48 7 SR 66.6 66 −0.6
6 F 75 160 30.1 ARDS 79 10 Afib 58.5 61 2.5
7 F 72 160 25.4 Trauma 66 6 SR 54 66 12
8 M 73 174 26.4 TBI 59 8 SR 65.7 66 0.3
9 M 41 190 24.9 AI 54 8 Afib 69.3 71 1.7
10 M 66 174 29.4 Trauma 32 8 SR 66.6 68 1.4
11 M 63 170 26.0 TBI 51 10 SR 61.2 63 1.8
12 M 78 176 24.2 CHD 38 8 Afib 61.8 66 4.2
13 F 64 162 24.8 ARF 59 10 SR 58.2 57 −1.2
14 M 86 175 26.1 Trauma 63 8 SR 64.8 69 4.2
15 F 87 163 24.1 CHF 45 8 SR 59 63 4
16 M 54 189 23.8 TBI 20 7 SR 65 67 2
17 F 64 165 22.0 SAH 58 8 SR 62.1 65 2.9
18 M 68 170 29.4 CHD 19 8 SR 63.9 66 2.1
19 M 82 178 27.5 CHD 24 10 Afib 71.1 69 −2.1
20 M 78 167 19.7 AS 35 6 Afib 61.2 61 −0.2
21 M 35 180 23.1 Sepsis 47 12 SR 68.4 69 0.6
22 F 64 169 26.6 Sepsis 93 10 Afib 63.9 65 1.1
23 F 81 158 22.0 CHD 75 8 SR 61.2 66 4.8
24 M 77 165 29.4 ICH 53 10 SR 63 67 4
25 M 40 185 27.8 Trauma 64 12 SR 69 69 0
25 + 1 M 40 179 32.6 CHF 72 BVAD
Median (Q25/Q75) 68 (55/78) 170 (165/180) 26 (24.1/29.4) 52 (40/64) 8 (8/10) 63.9 (61.2/66.6) 66 (65/68) 1.8 (0/4)
Mean ± SD 65.3 ± 16.0 172.3 ± 11.0 26.4 ± 3.6 51.2 ± 18.0 8.7 ± 1.6 63.5 ± 4.3 65.7 ± 3.3 2.2 ± 3.1

The median exact catheter position estimated by NEXmod was 64 cm compared to 66 cm detected by optimal catheter positioning (OPT) based on a stable EAdi signal, electrical activity highlighted in the central leads of the catheter positioning tool and the absence of p-waves in the distal lead

M male, F female, CHD coronary heart disease, TBI traumatic brain injury, CPR post cardiopulmonary resucitation, AS aortic valve stenosis, ARDS adult respiratory distress syndrome, Trauma severe trauma other than TBI, AI aortic valve insufficiency, ARF acute renal failure, CHF congestive heart failure, SAH subarachnoid hemorrhage, ICH intracerebral hemorrhage, Afib atrial fibrillation, BVAD biventricular cardiac assist device, SR sinus rhythm



Article Categories:
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Keywords: Keywords Neurally adjusted ventilatory assist (NAVA), Neural control, Electrical activation of the diaphragm (EAdi).

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