| Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol. | |
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MedLine Citation:
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PMID: 17409109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: It has been reported that carvedilol improves cardiac sympathetic nerve activity (CSNA) in patients with dilated cardiomyopathy (DCM). However, the influence of carvedilol on cardiac (123)I-meta-iodobenzylguanidine (MIBG) scintigraphic findings and left ventricular (LV) remodelling has not been determined in DCM patients. METHODS AND RESULTS: In 30 patients with DCM and 10 normal controls, the delayed heart/mediastinum count (H/M) ratio, delayed total defect score (TDS), and washout rate (WR) were determined by (123)I-MIBG scintigraphy. In addition, the left ventricular end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were calculated by echocardiography. In the DCM patients, the regional defect score index (RDSI), regional washout rate index (RWRI), and wall motion score index (WMSI) were also determined to evaluate regional adrenergic dysfunction and wall motion. Examinations were repeated in all DCM patients after standard treatment containing carvedilol at a dose of 10-20 mg/day (mean dose: 16 +/- 4 mg/day) for a mean of 12 +/- 1 months. Both the (123)I-MIBG scintigraphic and echocardiographic parameters were significantly worse in the DCM patients than the normal control subjects. After treatment, all of these parameters improved significantly in the DCM patients. There was a significant correlation between the changes of (123)I-MIBG findings and changes of the LVEDV and LVESV after treatment. Moreover, there was a significant correlation between changes of the WMSI and those of the RDSI or RWRI in DCM patients. CONCLUSION: Both (123)I-MIBG scintigraphic parameters and echocardiographic parameters were improved in the DCM patients. There was a significant correlation between the changes of (123)I-MIBG scintigraphic and echocardiographic findings after treatment. These findings implicate that long-term, including carvedilol, therapy can improve both CSNA and LV remodelling in patients with DCM. |
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Authors:
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Shu Kasama; Takuji Toyama; Takashi Hatori; Hiroyuki Sumino; Hisao Kumakura; Yoshiaki Takayama; Shuichi Ichikawa; Tadashi Suzuki; Masahiko Kurabayashi |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2007-04-04 |
Journal Detail:
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Title: European heart journal Volume: 28 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 989-95 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Gunma University School of Medicine, 3-39-15, Showa-machi, Maebashi, Gunma 371-0034, Japan. s-kasama@bay.wind.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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diagnostic use Adrenergic beta-Antagonists / therapeutic use* Adult Aged Blood Pressure / physiology Carbazoles / therapeutic use* Cardiomyopathy, Dilated / drug therapy, physiopathology*, radionuclide imaging Echocardiography Female Heart / innervation* Heart Rate / physiology Humans Male Middle Aged Natriuretic Peptide, Brain / metabolism Propanolamines / therapeutic use* Prospective Studies Radiopharmaceuticals / diagnostic use Stroke Volume / physiology Sympathetic Nervous System / drug effects* Tomography, Emission-Computed, Single-Photon / methods Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0/Radiopharmaceuticals; 114471-18-0/Natriuretic Peptide, Brain; 72956-09-3/carvedilol; 77679-27-7/3-Iodobenzylguanidine |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2007 Apr;28(8):922-3
[PMID:
17409108
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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