Document Detail

Evaluation of cardiac functions in patients with thalassemia major.
MedLine Citation:
PMID:  10435378     Owner:  NLM     Status:  MEDLINE    
It is known that a blood transfusion is necessary for survival in patients with thalassemia, but it may cause myocardial dysfunction due to myocardial siderosis as in other organs. The aim of this study was to evaluate myocardial perfusion by means of stress thallium scanning (MPS) and left ventricular functions by rest radionuclide ventriculography (RNV). Twenty-one patients at ages 9-16 (mean 12.1 +/- 3.2) who have been diagnosed with thalassemia for 4-15 years (mean 12.7 +/- 4.8) were included in the study. They had blood transfusions 78-318 times (mean 162.1 +/- 71). MPS and RNV was performed within two days after the any transfusion. MPS showed ischemia in 3 patients and normal perfusion in 18 patients. RNV revealed normal systolic parameters (wall motion, EF, PER, TPE) but diminished diastolic parameters (TPF, PFR) compared with normal values (p < 0.05). We conclude that ischemia or fixed defects may be seen in stress MPS as a result of cardiac involvement in patients with thalassemia. But, RNV is an important and preferable test for the early detection of subclinic cardiomyopathy. RNV may therefore show diastolic abnormalities before the systolic abnormalities show up.
N O Küçük; G Aras; T Sipahi; E Ibiş; N Akar; A Soylu; G Erbay
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  13     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-24     Completed Date:  1999-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Department of Nuclear Medicine, Ankara University Medical School, Turkey.
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MeSH Terms
Cardiac Output
Heart Function Tests*
Myocardial Ischemia / diagnosis*,  etiology*
Radionuclide Ventriculography
Radiopharmaceuticals / diagnostic use
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon / methods
beta-Thalassemia / complications*,  physiopathology*
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Thallium Radioisotopes

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