| Evaluation of a capillary gas chromatographic impurity test procedure for 4-hexylaniline. | |
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MedLine Citation:
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PMID: 15975246 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A capillary gas chromatographic test procedure for the detection and quantitation of impurities in the bulk intermediate, 4-hexylaniline, is evaluated and found to be accurate and precise. 4-Hexylaniline is dissolved in methanol and chromatographed isothermally at a temperature of 195 degrees C on a 60-m x 0.32-mm 85% polyethylene glycol-15% dimethylsilicone blend (DX-4) film column. A flame ionization detector is used, and the impurities in the parent compound are estimated from peak areas on a percent basis compared with the area of the parent peak in the chromatogram. Response factors are determined for the known impurities. Validation of this test method includes a recovery study of known impurity spiked samples fortified in the range of 0.1-1% (w/w). A repeatability study is performed, consisting of the analysis of two different synthetic batch lots of 4-hexylaniline analyzed over three experimental run days using two chromatographic columns of different manufacturing lots. These data and other aspects of this test procedure are discussed. |
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Authors:
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C B'Hymer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatographic science Volume: 43 ISSN: 0021-9665 ISO Abbreviation: J Chromatogr Sci Publication Date: 2005 May-Jun |
Date Detail:
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Created Date: 2005-06-24 Completed Date: 2005-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173225 Medline TA: J Chromatogr Sci Country: United States |
Other Details:
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Languages: eng Pagination: 267-70 Citation Subset: - |
Affiliation:
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University of Cincinnati, Mail Location 0172, Cincinnati, OH 45221-0172, USA. bhymerc@email.uc.edu |
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